Association of inflammatory response and oxidative injury in the pathogenesis of liver steatosis and insulin resistance following subchronic exposure to malathion in rats

• Published in: Environmental toxicology and pharmacology Vol. 38; no. 2; pp. 542 - 553
• Main Authors: Lasram, Mohamed Montassar, Dhouib, Ines Bini, Bouzid, Kahna, Lamine, Aicha Jrad, Annabi, Alya, Belhadjhmida, Nadia, Ahmed, Malika Ben, Fazaa, Saloua El, Abdelmoula, Jaouida, Gharbi, Najoua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2014; Elsevier
• Subjects: Animals; Biomarkers - blood; Blood Glucose - metabolism; Chemical and Drug Induced Liver Injury - immunology; Chemical and Drug Induced Liver Injury - pathology; Cytokines - immunology; Cytokines - metabolism; Emergency; Fatty Liver - chemically induced; Fatty Liver - immunology; Fatty Liver - pathology; Gene Expression Regulation - drug effects; Hepatosteatosis; Human health and pathology; Hépatology and Gastroenterology; Inflammation; Inflammation - chemically induced; Insulin Resistance; Life Sciences; Lipid Peroxidation - drug effects; Malathion; Malathion - toxicity; Male; Maximum Tolerated Dose; Oxidative stress; Oxidative Stress - drug effects; Pesticides - toxicity; Rats; Rats, Wistar; Toxicology; CTR; Pancreatic β-cell function; ALP; ALT; Activator Protein 1; Bilirubin; malathion-treated rats; MDA; MPO; Interleukin-1 beta; INF-γ; IκB kinase; Organophosphorus; NF-κB; Lactate deshydrogenase; Aspartate transaminase; Cluster of differentiation 8 (transmembrane glycoprotein); HOMA-β; control rats; Cluster of differentiation 4 (cell-surface glycoprotein); Glutathione peroxidase; STATs; TBARS; Malathion; Butyrylcholinesterase; IL-1β; GPx; IL-6; Insulin receptor substrate; Malondialdehyde; HOMA-IR; OPs; Hepatosteatosis; CAT; ROS; MAL; GAPDH; Suppressor cytokine signaling 3; Knock-out; Interferon gamma; Alkaline phosphatase; BChE; Oxidative stress; Reactive Oxygen Species; Cluster of differentiation 3 (T-cell coreceptor); BLR; Superoxide dismutase; IRS; Interleukin-6; LDH; Catalase; Myeloperoxidase; glyceraldehyde-3-phosphate dehydrogenase; Glutathione S-transferase; GSH; Tumor necrosis factor α; Reduced glutathione; AP1; AST; KO; SP-1; IKK; thiobarbituric acid reactive substances; GST; SOCS-3; SOD; Inflammation; Specific protein 1; CD4; CD3; Homeostasis model assessment for insulin resistance; Signal Transducers and Activators of Transcription; TNF-α; JAK; CD8; Alanine transaminase; C-Jun N-terminal kinases; Nuclear Factor-kappa B; Insulin resistance
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2014.08.007

Graphical abstract