Noncontrast Computed Tomography-Based Radiomics Analysis in Discriminating Early Hematoma Expansion after Spontaneous Intracerebral Hemorrhage

• Published in: Korean journal of radiology Vol. 22; no. 3; pp. 415 - 424
• Main Authors: Song, Zuhua, Guo, Dajing, Tang, Zhuoyue, Liu, Huan, Li, Xin, Luo, Sha, Yao, Xueying, Song, Wenlong, Song, Junjie, Zhou, Zhiming
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Radiology 01.03.2021; 대한영상의학회
• Subjects: Aged; Algorithms; Area Under Curve; Artificial intelligence; Cerebral Hemorrhage - complications; Cerebral Hemorrhage - pathology; Correlation analysis; Female; Hematoma; Hematoma - diagnosis; Hematoma - diagnostic imaging; Hematoma - etiology; Hemorrhage; Hospitals; Humans; Laboratories; Logistic Models; Machine Learning; Male; Management decisions; Mann-Whitney U test; Medical imaging; Middle Aged; Mortality; Neuroimaging and Head & Neck; Patients; Retrospective Studies; ROC Curve; Scanners; Tomography; Tomography, X-Ray Computed; 방사선과학; Hematoma expansion; Computed tomography; Intracerebral hemorrhage; Machine learning; Radiomics
• ISSN: 1229-6929; 2005-8330
• DOI: 10.3348/kjr.2020.0254

To determine whether noncontrast computed tomography (NCCT) models based on multivariable, radiomics features, and machine learning (ML) algorithms could further improve the discrimination of early hematoma expansion (HE) in patients with spontaneous intracerebral hemorrhage (sICH). We retrospectively reviewed 261 patients with sICH who underwent initial NCCT within 6 hours of ictus and follow-up CT within 24 hours after initial NCCT, between April 2011 and March 2019. The clinical characteristics, imaging signs and radiomics features extracted from the initial NCCT images were used to construct models to discriminate early HE. A clinical-radiologic model was constructed using a multivariate logistic regression (LR) analysis. Radiomics models, a radiomics-radiologic model, and a combined model were constructed in the training cohort (n = 182) and independently verified in the validation cohort (n = 79). Receiver operating characteristic analysis and the area under the curve (AUC) were used to evaluate the discriminative power. The AUC of the clinical-radiologic model for discriminating early HE was 0.766. The AUCs of the radiomics model for discriminating early HE built using the LR algorithm in the training and validation cohorts were 0.926 and 0.850, respectively. The AUCs of the radiomics-radiologic model in the training and validation cohorts were 0.946 and 0.867, respectively. The AUCs of the combined model in the training and validation cohorts were 0.960 and 0.867, respectively. NCCT models based on multivariable, radiomics features and ML algorithm could improve the discrimination of early HE. The combined model was the best recommended model to identify sICH patients at risk of early HE.