Bactericidal activity, post antibiotic effect and modified controlled effective regrowth time of meropenem at high concentrations

• Published in: Journal of antimicrobial chemotherapy Vol. 38; no. 6; pp. 1055 - 1060
• Main Authors: Bowker, Karen E., Holt, H. Alan, Reeves, David S., MacGowan, Alasdair P.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.12.1996
• Subjects: Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Enterobacter - drug effects; Enterobacter - growth & development; Escherichia coli - drug effects; Escherichia coli - growth & development; Gram-Negative Bacteria - drug effects; Gram-Negative Bacteria - growth & development; Gram-Positive Bacteria - drug effects; Gram-Positive Bacteria - growth & development; Kinetics; Klebsiella - drug effects; Klebsiella - growth & development; Medical sciences; Meropenem; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - growth & development; Staphylococcus aureus - drug effects; Staphylococcus aureus - growth & development; Thienamycins - pharmacology; Human; Microorganism growth; Intravenous administration; Single dose; Bioavailability; In vitro; Biological activity; Dose activity relation; In vivo; Antibiotic; Carbapenem derivatives; Absorption; Meropenem; Inhibition; Activity spectrum; Antibacterial agent; Postantibiotic effect; Pharmacokinetics; Delay effect
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/38.6.1055

The effect of increasing meropenem concentrations up to 250 mg/L, as might occur if 3 g was given as a single daily intravenous dose, was investigated in terms of bactericidal activity, post antibiotic effect (PAE) and modified controlled effective regrowth time (mCERT). Increasing the meropenem concentration above 50 mg/L did not result in increased bacterial killing, while concentrations over 75 mg/L did not result in longer PAE or mCERT.