Fabrication of terazocin-loaded poly(D,L-lactide) microspheres by an ultrasonic spray drying method and their release behaviors

• Published in: Journal of nanoscience and nanotechnology Vol. 8; no. 10; p. 5139
• Main Authors: An, Guk-Hwan, Kim, Min-Jung, Lee, Hak-Jong, Park, Sang-Soo, Cho, Yong Woo, Park, Kinam, Choa, Yong-Ho
• Format: Journal Article
• Language: English
• Published: United States 01.10.2008
• Subjects: Microscopy, Electron, Scanning; Polyesters - chemistry; Prazosin - analogs & derivatives; Prazosin - chemistry; Spectroscopy, Fourier Transform Infrared; Ultrasonics
• ISSN: 1533-4880
• DOI: 10.1166/jnn.2008.1138

Terazocin should be frequently administered for a long period time for the treatment of benign prostatic hyperplasia which is one of the most common diseases in elderly men. Controlled delivery of terazocin using polymer microspheres has a great potential to solve the problem. In this study, terazocin-incorporated poly(D,L-lactide) (PDLLA) microspheres were fabricated by a novel ultrasonic spray drying (USD) method, which is a rapid one-step process. The approximate diameters of microspheres were in a range of between 0.3 and 3 microm. SEM confirmed that the microspheres had a spherical shape and narrow size distribution. FT-IR spectroscopy demonstrated that the incorporated terazocin remained intact after the USD process. The microspheres showed a fast initial burst release of terazocin within nine hours, followed by a slow but steady release for 49 days, suggesting that these microspheres are highly promising for controlled drug delivery.