ANTI-INFLAMMATORY ACTIVITY OF TAXIFOLIN

Active principles of varied chemical structure isolated from plants possess potent anti-inflammatory activity. The anti-inflammatory activity of triterpenoids, saponins and other natural products has been reported from this laboratory (1-3). The flavonoids viz hesperidin, neohesperidin and naringin...

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Bibliographic Details
Published inJapanese journal of pharmacology Vol. 21; no. 3; pp. 377 - 382
Main Authors GUPTA, M.B., BHALLA, T.N., GUPTA, G.P., MITRA, C.R., BHARGAVA, K.P.
Format Journal Article
LanguageEnglish
Published The Japanese Pharmacological Society 1971
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Summary:Active principles of varied chemical structure isolated from plants possess potent anti-inflammatory activity. The anti-inflammatory activity of triterpenoids, saponins and other natural products has been reported from this laboratory (1-3). The flavonoids viz hesperidin, neohesperidin and naringin have been shown to reduce formalin-induced oedema in the mouse foot (4). The present investigation deals with the study of the antiinflammatory activity of taxifolin, a flavonoid obtained from Madhuca Butyracea, and the effect of taxifolin on the serum aminotransferase and tissue adenosine triphosphate (ATP) phosphohydrolase activity to elucidate the possible mechanism of its anti-inflammatory activity. The structure of the compound elucidated by Giessmann and Lichner (5) is shown in Fig. 1.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.21.377