Green Synthesis of Silver Nanoparticles Coated by Water Soluble Chitosan and Its Potency as Non-Alcoholic Hand Sanitizer Formulation

The synthesis of silver nanoparticles using plant extracts, widely known as a green synthesis method, has been extensively studied. Nanoparticles produced through this method have applications as antibacterial agents. Bacterial and viral infection can be prevented by use of antibacterial agents such...

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Published inMaterials Vol. 15; no. 13; p. 4641
Main Authors Wulandari, Ika O., Pebriatin, Baiq E., Valiana, Vita, Hadisaputra, Saprizal, Ananto, Agus D., Sabarudin, Akhmad
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.07.2022
MDPI
Subjects
Biocompatibility
Chitosan
Coronaviruses
COVID-19
Fourier transforms
Functional groups
Gels
green synthesis
hand sanitizer
Manufacturing
nanoparticle
Nanoparticles
Pathogens
Polyethylene glycol
Polymers
Polyvinyl alcohol
Sanitizers
Silver
Skin
Spectrum analysis
Syneresis
Synthesis
Singapore
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Summary:The synthesis of silver nanoparticles using plant extracts, widely known as a green synthesis method, has been extensively studied. Nanoparticles produced through this method have applications as antibacterial agents. Bacterial and viral infection can be prevented by use of antibacterial agents such as soap, disinfectants, and hand sanitizer. Silver nanoparticles represent promising hand sanitizer ingredients due to their antibacterial activity and can enable reduced use of alcohol and triclosan. This study employed silver nanoparticles synthesized using Kepok banana peel extract (Musa paradisiaca L.). Nanoparticle effectiveness as a hand sanitizer can be enhanced by coating with a biocompatible polymer such as chitosan. The characterization of silver nanoparticles was conducted using UV-Vis, with an obtained peak at 434.5 nm. SEM-EDX analysis indicated nanoparticles with a spherical morphology. Silver nanoparticles coated with chitosan were characterized through FTIR to verify the attached functional groups. Gel hand sanitizers were produced using silver nanoparticles coated with different chitosan concentrations. Several tests were undertaken to determine the gel characteristics, including pH, syneresis, and antibacterial activity. Syneresis leads to unstable gels, but was found to be inhibited by adding chitosan at a concentration of 2%. Antibacterial activity was found to increase with increase in chitosan concentration.
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ISSN:1996-1944
1996-1944
DOI:10.3390/ma15134641