Quantitative detection of chemical compounds in human hair with coherent anti-Stokes Raman scattering microscopy

Coherent anti-Stokes Raman scattering (CARS) microscopy is used to determine the distribution and concentration of selected compounds in intact human hair. By generating images based on ratiometric CARS contrast, quantitative concentration maps of both water and externally applied d-glycine are prod...

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Bibliographic Details
Published inJournal of Biomedical Optics Vol. 14; no. 4; pp. 044019 - 044017
Main Authors Zimmerley, Maxwell, Lin, Chia-Yu, Oertel, David C, Marsh, Jennifer M, Ward, Jimmie L, Potma, Eric Olaf
Format Journal Article
LanguageEnglish
Published United States 01.07.2009
Subjects
Algorithms
Body Water - chemistry
Coherent scattering
Fibers
Hair
Hair - chemistry
Human
Humans
Image contrast
medical imaging
Microscopy
Microscopy - methods
molecular spectroscopy
multiphoton process
Raman scattering
Raman spectroscopy
Skin Tests - methods
Spectrum Analysis, Raman - methods
water
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Summary:Coherent anti-Stokes Raman scattering (CARS) microscopy is used to determine the distribution and concentration of selected compounds in intact human hair. By generating images based on ratiometric CARS contrast, quantitative concentration maps of both water and externally applied d-glycine are produced in the cortex of human hair fibers. Both water and d-glycine are found to homogeneously distribute throughout the cortical regions of the hair. The ability to selectively detect molecular agents in hair fibers is of direct relevance to understanding the chemical and physical mechanisms that underlie the performance of hair-care products.
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ISSN:1083-3668
1560-2281
DOI:10.1117/1.3184444