Vitamin A Supplementation and Human Immunodeficiency Virus Type 1 Shedding in Women: Results of a Randomized Clinical Trial

• Published in: The Journal of infectious diseases Vol. 185; no. 8; pp. 1187 - 1191
• Main Authors: Baeten, Jared M., McClelland, Scott, Overbaugh, Julie, Richardson, Barbra A., Emery, Sandra, Lavreys, Ludo, Mandaliya, Kishorchandra, Bankson, Daniel D., Ndinya-Achola, Jeckoniah O., Bwayo, Job J., Kreiss, Joan K.
• Format: Journal Article
• Language: English
• Published: Chicago, IL University of Chicago Press 15.04.2002; Oxford University Press
• Subjects: Acquired Immunodeficiency Syndrome - immunology; Acquired Immunodeficiency Syndrome - virology; Adolescent; Adult; Biological and medical sciences; Concise Communications; Dietary Supplements; DNA; Double-Blind Method; Experimentation; Female; Follow-Up Studies; HIV; HIV 1; HIV-1 - drug effects; HIV-1 - physiology; Human immunodeficiency virus 1; Human viral diseases; Humans; Infections; Infectious diseases; Medical sciences; Middle Aged; Placebos; RNA; Vagina - virology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Virus Shedding - drug effects; Vitamin A; Vitamin A - administration & dosage; Vitamin A deficiency; Vitamin A Deficiency - immunology; Women; Human; Immunopathology; HIV-1 virus; Secretion; Vitamin; Retroviridae; Vagina; AIDS; Immune deficiency; Lentivirus; Retinol; Infection; Virus; Prevention; Viral disease; Female genital system; Female; Vertical transmission; Human immunodeficiency virus; Food supplement

Observational studies have associated vitamin A deficiency with vaginal shedding of human immunodeficiency virus (HIV) type 1-infected cells and mother-to-child HIV-1 transmission. To assess the effect of vitamin A supplementation on vaginal shedding of HIV-1, a randomized, double-blind, placebo-con...