Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta as a potential biomarker for Opisthorchis viverrini infection and cholangiocarcinoma

• Published in: Parasitology Vol. 149; no. 2; pp. 171 - 180
• Main Authors: Prasopdee, Sattrachai, Yingchutrakul, Yodying, Roytrakul, Sittiruk, Pholhelm, Montinee, Phanaksri, Teva, Kunjantarachot, Anthicha, Kulsantiwong, Jutharat, Butthongkomvong, Kritiya, Tesana, Smarn, Sathavornmanee, Thanakrit, Thitapakorn, Veerachai
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.02.2022
• Subjects: AKT protein; Amino acids; Animals; Apoptosis; Bile Duct Neoplasms - diagnosis; Bile Duct Neoplasms - epidemiology; Bile Duct Neoplasms - metabolism; Bile ducts; Bile Ducts, Intrahepatic - metabolism; Bile Ducts, Intrahepatic - parasitology; Bile Ducts, Intrahepatic - pathology; Biomarkers; Biomarkers - analysis; Catalytic Domain; Cell cycle; Cell growth; Cholangiocarcinoma; Cholangiocarcinoma - diagnosis; Cholangiocarcinoma - etiology; Cholangiocarcinoma - metabolism; early diagnosis; Enzyme-linked immunosorbent assay; Humans; Infections; Kinases; Liver; liver flukes; opisthorchiasis; Opisthorchiasis - diagnosis; Opisthorchiasis - epidemiology; Opisthorchiasis - parasitology; Opisthorchis; Opisthorchis viverrini; Parasites; parasitology; Peptides; Phosphatidylinositol 4,5-diphosphate; Phosphatidylinositols - metabolism; phosphoproteome; Phosphoproteomes; Plasma; protein subunits; Proteins; Public health; Risk analysis; Risk factors; Sensitivity; Signal transduction; Signaling; Ultrasonic imaging; Thailand; United States > US; diagnosis; Biomarker; Phosphoproteome; PIK3CB; cholangiocarcinoma; Opisthorchis viverrini
• ISSN: 0031-1820; 1469-8161; 1469-8161
• DOI: 10.1017/S0031182021001694

The human liver fluke Opisthorchis viverrini (Ov), the primary risk factor for cholangiocarcinoma (CHCA), is a parasite endemic to southeast Asian countries. With no effective treatments for CHCA currently available, early diagnosis and treatment of Ov infection remains the only practical method for...