A Deeper Look into Translation Initiation

• Published in: Cell Vol. 159; no. 3; pp. 475 - 476
• Main Author: Korostelev, Andrei A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.10.2014
• Subjects: Animals; Eukaryotic Initiation Factor-1 - chemistry; Eukaryotic Initiation Factor-3 - chemistry; Eukaryotic Initiation Factors - metabolism; Humans; Kluyveromyces - metabolism; Peptide Chain Initiation, Translational; Ribosome Subunits, Small, Eukaryotic - chemistry; Saccharomyces cerevisiae - chemistry; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - chemistry
• ISSN: 0092-8674; 1097-4172
• DOI: 10.1016/j.cell.2014.10.005

Eukaryotic translation initiation requires coordinated assembly of a remarkable array of initiation factors onto the small ribosomal subunit to select an appropriate mRNA start codon. Studies from Erzberger et al. and Hussain et al. bring new insights into this mechanism by looking at early and late initiation intermediates. Eukaryotic translation initiation requires coordinated assembly of a remarkable array of initiation factors onto the small ribosomal subunit to select an appropriate mRNA start codon. Studies from Erzberger et al. and Hussain et al. bring new insights into this mechanism by looking at early and late initiation intermediates.