Identification of Promising Antifungal Drugs against Scedosporium and Lomentospora Species after Screening of Pathogen Box Library

Fungal infections have been increasing during the last decades. Scedosporium and Lomentospora species are filamentous fungi most associated to those infections, especially in immunocompromised patients. Considering the limited options of treatment and the emergence of resistant isolates, an increasi...

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Published inJournal of fungi (Basel) Vol. 7; no. 10; p. 803
Main Authors Rollin-Pinheiro, Rodrigo, Borba-Santos, Luana Pereira, da Silva Xisto, Mariana Ingrid Dutra, de Castro-Almeida, Yuri, Rochetti, Victor Pereira, Rozental, Sonia, Barreto-Bergter, Eliana
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 25.09.2021
MDPI
Subjects
Acquired immune deficiency syndrome
AIDS
Antifungal activity
Antifungal agents
antifungal drugs
biofilm
Biofilms
Caspofungin
drug repurposing
Drugs
Experiments
Fluconazole
fungal growth
Fungal infections
Fungi
Glucose
HIV
Human immunodeficiency virus
Immunocompromised hosts
Iodoquinol
Libraries
Malaria
Mutation
Pathogen Box
Pathogens
Planktonic cells
Scanning electron microscopy
Scedosporium
Tropical diseases
Voriconazole
St Louis Missouri
United States > US
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Summary:Fungal infections have been increasing during the last decades. Scedosporium and Lomentospora species are filamentous fungi most associated to those infections, especially in immunocompromised patients. Considering the limited options of treatment and the emergence of resistant isolates, an increasing concern motivates the development of new therapeutic alternatives. In this context, the present study screened the Pathogen Box library to identify compounds with antifungal activity against Scedosporium and Lomentospora. Using antifungal susceptibility tests, biofilm analysis, scanning electron microscopy (SEM), and synergism assay, auranofin and iodoquinol were found to present promising repurposing applications. Both compounds were active against different Scedosporium and Lomentospora, including planktonic cells and biofilm. SEM revealed morphological alterations and synergism analysis showed that both drugs present positive interactions with voriconazole, fluconazole, and caspofungin. These data suggest that auranofin and iodoquinol are promising compounds to be studied as repurposing approaches against scedosporiosis and lomentosporiosis.
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ISSN:2309-608X
2309-608X
DOI:10.3390/jof7100803