Therapeutic Potential of Marine Bioactive Peptides against Human Immunodeficiency Virus: Recent Evidence, Challenges, and Future Trends

• Published in: Marine drugs Vol. 20; no. 8; p. 477
• Main Authors: Al-Khayri, Jameel Mohammed, Asghar, Waqas, Khan, Sipper, Akhtar, Aqsa, Ayub, Haris, Khalid, Nauman, Alessa, Fatima Mohammed, Al-Mssallem, Muneera Qassim, Rezk, Adel Abdel-Sabour, Shehata, Wael Fathi
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 25.07.2022; MDPI
• Subjects: Acquired immune deficiency syndrome; AIDS; Algae; Amino acids; anti-HIV; Antimicrobial agents; Antiretroviral agents; bioactive peptides; Biological activity; Chemokines; Chronic illnesses; Clinical trials; Cytotoxicity; drugs; Enzymes; Functional foods & nutraceuticals; HIV; Human immunodeficiency virus; Immune system; Marine organisms; Pelodiscus sinensis; Peptides; Protein purification; Review; Trends; Water purification
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md20080477

Acquired immunodeficiency syndrome (AIDS) is a chronic and potentially fatal ailment caused by the human immunodeficiency virus (HIV) and remains a major health problem worldwide. In recent years, the research focus has shifted to a greater emphasis on complementing treatment regimens involving conventional antiretroviral (ARV) drug therapies with novel lead structures isolated from various marine organisms that have the potential to be utilized as therapeutics for the management of HIV-AIDS. The present review summarizes the recent developments regarding bioactive peptides sourced from various marine organisms. This includes a discussion encompassing the potential of these novel marine bioactive peptides with regard to antiretroviral activities against HIV, preparation, purification, and processing techniques, in addition to insight into the future trends with an emphasis on the potential of exploration and evaluation of novel peptides to be developed into effective antiretroviral drugs.