The Novel Anti-Rheumatic Drug TA-383 Has a Macrophage Migration Enhancing Activity

• Published in: Japanese journal of pharmacology Vol. 74; no. 2; pp. 221 - 224
• Main Authors: Ueno, Makoto, Sugita, Takahisa, Murakami, Takanori, Takata, Isao
• Format: Journal Article
• Language: English
• Published: The Japanese Pharmacological Society 1997
• Subjects: Collagen-induced arthritis; Macrophage migration enhancement activity; TA-383
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1254/jjp.74.221

We have investigated the effect of a novel anti-rheumatic drug, cis-2-(4-chlorophenyl)-4, 5-diphenyl-2-imidazoline hydrochloride (TA-383), on macrophages. TA-383 (≥10-9 M)significantly stimulated rabbit alveolar macrophage (AM)migration, and its migration-stimulatory activity was more potent than those of L-fucose (5 × 10-3 M), lobenzarit disodium, bucillamine (SA-96)and salazosulfapyridine. In addition, TA-383 enhanced the production and/or release of macrophage migration enhancement factor by rabbit spleen cells. In vivo, TA-383 (0.4 mg/kg, p.o.)has suppressive effects on picryl chloride-induced delayed type hypersensitivity and type II collagen-induced arthritis in mice. These results suggest that the anti-rheumatic activity of TA-383 may be exerted through the dispersion of macrophages from inflammatory sites.