Management complexities of HIV/hepatitis C virus coinfection in the twenty-first century

Because of shared routes of transmission, hepatitis C virus (HCV) coinfection is common among HIV-infected persons. Because of the effectiveness of antiretroviral therapy, chronic HCV has now emerged as a major cause of morbidity and mortality in this population. Because chronic HCV is highly preval...

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Bibliographic Details
Published inClinics in liver disease Vol. 12; no. 3; p. 587
Main Authors Lo Re, 3rd, Vincent, Kostman, Jay R, Amorosa, Valerianna K
Format Journal Article
LanguageEnglish
Published United States 01.08.2008
Subjects
AIDS-Related Opportunistic Infections - drug therapy
Antiviral Agents - therapeutic use
Comorbidity
Hepatitis C, Chronic - drug therapy
HIV
Humans
Treatment Outcome
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Summary:Because of shared routes of transmission, hepatitis C virus (HCV) coinfection is common among HIV-infected persons. Because of the effectiveness of antiretroviral therapy, chronic HCV has now emerged as a major cause of morbidity and mortality in this population. Because chronic HCV is highly prevalent among HIV-infected patients and has a rapid disease progression, antiviral therapy with pegylated interferon plus ribavirin is critical for the long-term survival of HIV/HCV-coinfected patients. In this article, the authors review the (1) epidemiology of HCV among HIV-infected individuals, (2) effect of HIV on the natural history of chronic HCV, (3) impact of antiretroviral therapy on HCV coinfection, and (4) management of chronic HCV in the HIV-infected person.
ISSN:1089-3261
DOI:10.1016/j.cld.2008.03.009