Transdermal microemulsion drug delivery system for impairing male reproductive toxicity and enhancing efficacy of Tripterygium Wilfordii Hook f

• Published in: Fitoterapia Vol. 83; no. 4; pp. 690 - 698
• Main Authors: Wang, Xiao, Xue, Mei, Gu, Jijin, Fang, Xiaoling, Sha, Xianyi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.06.2012; Elsevier
• Subjects: Administration, Cutaneous; Animals; anti-inflammatory activity; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - therapeutic use; Anti-Inflammatory Agents - toxicity; arthritis; Arthritis - chemically induced; Arthritis - prevention & control; Biological and medical sciences; Chemical and Drug Induced Liver Injury - prevention & control; Drug Delivery Systems; drugs; Emulsions; ethanol; General pharmacology; hepatotoxicity; Male; Male Urogenital Diseases - chemically induced; Male Urogenital Diseases - prevention & control; Medical sciences; Microemulsion; oleic acid; Pharmacodynamics; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - administration & dosage; Plant Extracts - therapeutic use; Plant Extracts - toxicity; Rats; reproductive toxicology; response surface methodology; Toxicity; Transdermal delivery system; Tripterygium - toxicity; Tripterygium wilfordii; TWHF; Water - chemistry; Asia; China; Transdermal delivery system; Pharmacodynamics; Microemulsion; Toxicity; TWHF; Delivery system; Transdermal system; Pharmacognosy; Celastraceae; Male; Drug carrier; Biological activity; Medicinal plant; Percutaneous route; Folk medicine; Efficiency; Dicotyledones; Angiospermae; Plant origin; Dosage form; Spermatophyta; Tripterygium wilfordii
• ISSN: 0367-326X; 1873-6971
• DOI: 10.1016/j.fitote.2012.02.006

The present study is trying to produce a transdermal microemulsion drug delivery system (TMDDS) for Tripterygium Wilfordii Hook f. (TWHF) and attempting to solve male reproductive toxicity problem of TWHF. The formulation was optimized by the central composite design with response surface methodology and was decided as 12% oleic acid, 19.7% Labrasol S, 19.7% ethanol and 19.7% Pharmasolve, and 29% water. TMDDS for TWHF had stronger transdermal ability than free TWHF, and TWHF microemulsion significantly inhibited the adjuvant-induced arthritis and at the same time, had preferable anti-inflammatory effect with the long-time administration. Various pharmacodynamics parameters proved that TWHF microemulsion can reduce the male reproductive toxicity and hepatotoxicity of rats. All these suggested that TMDDS could be a suitable delivery system for TWHF. [Display omitted]