Epicardial Adipose Tissue and Diabetic Cardiomyopathy

Diabetes is a long-term chronic disease, and cardiovascular disease is the leading cause of death. Diabetic cardiomyopathy (DCM), one of the cardiovascular complications of diabetes, has many uncertain factors. Epicardial fat, as the heart fat bank, functions as fatty tissue and is the heart’s endoc...

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Bibliographic Details
Published inJournal of Cardiovascular Pharmacology and Therapeutics Vol. 28; p. 10742484231151820
Main Authors Yang, Xueyuan, Feng, Chao, Feng, Jinping
Format Book Review Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2023
SAGE Publishing
Subjects
Adipokines
Adipose Tissue
Cardiovascular Diseases
Diabetes Mellitus
Diabetic Cardiomyopathies
Humans
Pericardium
epicardial adipose tissue
autophagy
diabetic cardiomyopathy
insulin resistance
oxidative stress
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Summary:Diabetes is a long-term chronic disease, and cardiovascular disease is the leading cause of death. Diabetic cardiomyopathy (DCM), one of the cardiovascular complications of diabetes, has many uncertain factors. Epicardial fat, as the heart fat bank, functions as fatty tissue and is the heart’s endocrine organ. The existence of diabetes affects the distribution of heart fat and promotes the secretion of adipokine. In different pathological conditions, it can promote the secretion of pro-inflammatory adipokine, reactive oxygen species, oxidative stress, and even autophagy, thus affecting cardiac function. In this paper, we will elaborate on the mechanism of epicardial fat in the pathogenesis of diabetic cardiomyopathy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1074-2484
1940-4034
DOI:10.1177/10742484231151820