Crosstalk between Endothelial Cells and Tumor Cells: A New Era in Prostate Cancer Progression

Prostate cancer stands as one of the most prevalent malignancies afflicting men worldwide. The tumor microenvironment plays a pivotal role in tumor progression, comprising various cell types including endothelial cells, tumor-associated fibroblasts, and macrophages. Recent accumulating evidence unde...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 24; no. 23; p. 16893
Main Authors Ji, Shiyu, Wu, Wenbo, Jiang, Qi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.12.2023
Subjects
Angiogenesis
Blood vessels
Cancer therapies
Chemotherapy
Development and progression
Drug resistance
endothelial cells
Endothelium
Genes
Health aspects
Hypoxia
Metastasis
MicroRNAs
Permeability
Prostate cancer
Proteins
Temsirolimus
therapeutic applications
Transcription factors
tumor microenvironment
Vascular endothelial growth factor
endothelial cells
prostate cancer
tumor microenvironment
therapeutic applications
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Summary:Prostate cancer stands as one of the most prevalent malignancies afflicting men worldwide. The tumor microenvironment plays a pivotal role in tumor progression, comprising various cell types including endothelial cells, tumor-associated fibroblasts, and macrophages. Recent accumulating evidence underscores the indispensable contribution of endothelial cells to prostate cancer development. Both endothelial cells and tumor cells release a multitude of factors that instigate angiogenesis, metastasis, and even drug resistance in prostate cancer. These factors serve as regulators within the tumor microenvironment and represent potential therapeutic targets for managing prostate cancer. In this review, we provide an overview of the crucial functions of endothelial cells in angiogenesis, metastasis, and drug resistance, and their prospective therapeutic applications in combating this disease.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242316893