miRNAs as Interconnectors between Obesity and Cancer

• Published in: Non-coding RNA Vol. 10; no. 2; p. 24
• Main Authors: González-Sánchez, Grecia Denisse, Granados-López, Angelica Judith, López-Hernández, Yamilé, Robles, Mayra Judith García, López, Jesús Adrián
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2024
• Subjects: Adipocytes; Body fat; Body mass index; Cancer; Cell cycle; Cell signaling; Cervix; Colorectal cancer; Development and progression; DNA methylation; Down-regulation; Epigenetics; Gene expression; Homeostasis; Insulin; lncRNAs; Lung cancer; MAP kinase; Metabolism; MicroRNA; MicroRNAs; miRNA; miRNAs; Non-coding RNA; Obesity; Oncology, Experimental; Overweight; Peroxisome proliferator-activated receptors; Prostate; Protein expression; Proteins; Stem cells; Transcription factors; Tumorigenesis; Womens health; Mexico; lncRNAs; cancer; miRNAs; obesity
• ISSN: 2311-553X; 2311-553X
• DOI: 10.3390/ncrna10020024

Obesity and cancer are a concern of global interest. It is proven that obesity may trigger the development or progression of some types of cancer; however, the connection by non-coding RNAs has not been totally explored. In the present review, we discuss miRNAs and lncRNAs dysregulation involved in obesity and some cancers, shedding light on how these conditions may exacerbate one another through the dysregulation of ncRNAs. lncRNAs have been reported as regulating microRNAs. An in silico investigation of lncRNA and miRNA interplay is presented. Our investigation revealed 44 upregulated and 49 downregulated lncRNAs in obesity and cancer, respectively. miR-375, miR-494-3p, miR-1908, and miR-196 were found interacting with 1, 4, 4 and 4 lncRNAs, respectively, which are involved in PPARγ cell signaling regulation. Additionally, miR-130 was found to be downregulated in obesity and reported as modulating 5 lncRNAs controlling PPARγ cell signaling. Similarly, miR-128-3p and miR-143 were found to be downregulated in obesity and cancer, interacting with 5 and 4 lncRNAs, respectively, associated with MAPK cell signaling modulation. The delicate balance between miRNA and lncRNA expression emerges as a critical determinant in the development of obesity-associated cancers, presenting these molecules as promising biomarkers. However, additional and deeper studies are needed to reach solid conclusions about obesity and cancer connection by ncRNAs.