Tumor-Derived Membrane Vesicles: A Promising Tool for Personalized Immunotherapy

Tumor-derived membrane vesicles (TDMVs) are non-invasive, chemotactic, easily obtained characteristics and contain various tumor-borne substances, such as nucleic acid and proteins. The unique properties of tumor cells and membranes make them widely used in drug loading, membrane fusion and vaccines...

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Published inPharmaceuticals (Basel, Switzerland) Vol. 15; no. 7; p. 876
Main Authors Xu, Jiabin, Cao, Wenqiang, Wang, Penglai, Liu, Hong
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 16.07.2022
MDPI
Subjects
Antigens
Apoptosis
Cancer therapies
cancer therapy
Cell adhesion & migration
Drug delivery systems
Drugs
Extracellular matrix
Hematology
Immune system
Immunotherapy
Membranes
Metastasis
Monoclonal antibodies
Nanoparticles
personalized immunotherapy
Polyethylene glycol
Proteins
Review
tumor vaccine
tumor-derived membrane vesicles
Tumors
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Summary:Tumor-derived membrane vesicles (TDMVs) are non-invasive, chemotactic, easily obtained characteristics and contain various tumor-borne substances, such as nucleic acid and proteins. The unique properties of tumor cells and membranes make them widely used in drug loading, membrane fusion and vaccines. In particular, personalized vectors prepared using the editable properties of cells can help in the design of personalized vaccines. This review focuses on recent research on TDMV technology and its application in personalized immunotherapy. We elucidate the strengths and challenges of TDMVs to promote their application from theory to clinical practice.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1424-8247
1424-8247
DOI:10.3390/ph15070876