COVID-19-Associated Pulmonary Mucormycosis

COVID-19-associated mucormycosis (CAM) emerged as an epidemic in certain parts of the world amidst the global COVID-19 pandemic. While rhino–orbital mucormycosis was well reported during the pandemic, in the absence of routine diagnostic facilities including lower airway sampling, pulmonary mucormyc...

Full description

Saved in:
Bibliographic Details
Published inJournal of fungi (Basel) Vol. 8; no. 7; p. 711
Main Authors Krishna, Vidya, Bansal, Nitin, Morjaria, Jaymin, Kaul, Sundeep
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 05.07.2022
MDPI
Subjects
Biomarkers
Cavitation
Coronaviruses
COVID-19
Diabetes
Diagnosis
Epidemiology
Fungal infections
Fungi
Hematology
Hemoptysis
Illnesses
Influenza
Mucormycosis
Pandemics
Patients
Pleural effusion
Pneumonia
pulmonary mucor
respiratory infections
Review
Risk factors
Sampling
SARS CoV-2
Steroid hormones
Steroids
Transplants & implants
India
Online AccessGet full text

Cover

More Information
Summary:COVID-19-associated mucormycosis (CAM) emerged as an epidemic in certain parts of the world amidst the global COVID-19 pandemic. While rhino–orbital mucormycosis was well reported during the pandemic, in the absence of routine diagnostic facilities including lower airway sampling, pulmonary mucormycosis was probably under-recognized. In this review, we have focused on the epidemiology and management of COVID-19-associated pulmonary mucormycosis (CAPM). CAPM is a deadly disease and mortality can be as high as 80% in the absence of early clinical suspicion and treatment. While histopathological examination of tissue for angio-invasion and cultures have remained gold standard for diagnosis, there is an increasing interest in molecular and serological methods to facilitate diagnosis in critically ill patients and often, immune-suppressed hosts who cannot readily undergo invasive sampling. Combined medical and surgical treatment offers more promise than standalone medical therapy. Maintaining adequate glycemic control and prudent use of steroids which can be a double-edged sword in COVID-19 patients are the key preventative measures. We would like to emphasize the urgent need for the development and validation of reliable biomarkers and molecular diagnostics to facilitate early diagnosis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
These authors contributed equally to the work.
S.K. will be primary corresponding author.
ISSN:2309-608X
2309-608X
DOI:10.3390/jof8070711