Wide-field imaging of fluorescent deoxy-glucose in ex vivo malignant and normal breast tissue

Rapid in situ determination of surgical resection margins during breast cancer surgery would reduce patient time under anesthesia. We present preliminary data supporting the use of a fluorescent glucose analog (2-NBDG) as an optical contrast agent to differentiate freshly excised breast tissue conta...

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Published inBiomedical optics express Vol. 2; no. 6; pp. 1514 - 1523
Main Authors Langsner, R J, Middleton, L P, Sun, J, Meric-Bernstam, F, Hunt, K K, Drezek, R A, Yu, T K
Format Journal Article
LanguageEnglish
Published United States Optical Society of America 01.06.2011
Subjects
Optics in Cancer Research
(170.1610) Clinical applications
(170.3880) Medical and biological imaging
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Summary:Rapid in situ determination of surgical resection margins during breast cancer surgery would reduce patient time under anesthesia. We present preliminary data supporting the use of a fluorescent glucose analog (2-NBDG) as an optical contrast agent to differentiate freshly excised breast tissue containing cancerous cells from normal breast tissue. Multi-spectral images of 14 breast cancer specimens acquired before and after incubation with 2-NBDG demonstrated increased fluorescent signal in all of the malignant tissue due to increased 2-NBDG consumption. We demonstrate that 2-NBDG has potential as an optical contrast agent to differentiate cancerous from non-cancerous tissue.
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ISSN:2156-7085
2156-7085
DOI:10.1364/boe.2.001514