Oral Chronic Hyperplastic Candidiasis and Its Potential Risk of Malignant Transformation: A Systematic Review and Prevalence Meta-Analysis
Chronic hyperplastic candidiasis (CHC) is a prototypical oral lesion caused by chronic Candida infection. A major controversy surrounding CHC is whether this oral lesion owns malignant transformation (MT) potential. The aim of the present study was to evaluate current evidence on the MT of CHC and t...
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| Published in | Journal of fungi (Basel) Vol. 8; no. 10; p. 1093 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Basel
MDPI AG
17.10.2022
MDPI |
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| Online Access | Get full text |
| ISSN | 2309-608X 2309-608X |
| DOI | 10.3390/jof8101093 |
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| Abstract | Chronic hyperplastic candidiasis (CHC) is a prototypical oral lesion caused by chronic Candida infection. A major controversy surrounding CHC is whether this oral lesion owns malignant transformation (MT) potential. The aim of the present study was to evaluate current evidence on the MT of CHC and to determine the variables which have the greatest influence on cancer development. Bibliographical searches included PubMed, Embase, Web of Science, Scopus and LILACS. The cohort studies and case series used to investigate the MT of CHC were deemed suitable for inclusion. The quality of the enrolled studies was measured by the Joanna Briggs Institute scale. Moreover, we undertook subgroup analyses, assessed small study effects, and conducted sensitivity analyses. From 338 studies, nine were finally included for qualitative/quantitative analysis. The overall MT rate for CHC across all studies was 12.1% (95% confidential interval, 4.1–19.8%). Subgroup analysis showed that the MT rate increased when pooled analysis was restricted to poor quality studies. It remains complex to affirm whether CHC is an individual and oral, potentially malignant disorder according to the retrieved evidence. Prospective cohort studies to define the natural history of CHC and a consensus statement to clarify a proper set of diagnostic criteria are strongly needed. PROSPERO ID: CRD42022319572. |
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| AbstractList | Chronic hyperplastic candidiasis (CHC) is a prototypical oral lesion caused by chronic Candida infection. A major controversy surrounding CHC is whether this oral lesion owns malignant transformation (MT) potential. The aim of the present study was to evaluate current evidence on the MT of CHC and to determine the variables which have the greatest influence on cancer development. Bibliographical searches included PubMed, Embase, Web of Science, Scopus and LILACS. The cohort studies and case series used to investigate the MT of CHC were deemed suitable for inclusion. The quality of the enrolled studies was measured by the Joanna Briggs Institute scale. Moreover, we undertook subgroup analyses, assessed small study effects, and conducted sensitivity analyses. From 338 studies, nine were finally included for qualitative/quantitative analysis. The overall MT rate for CHC across all studies was 12.1% (95% confidential interval, 4.1-19.8%). Subgroup analysis showed that the MT rate increased when pooled analysis was restricted to poor quality studies. It remains complex to affirm whether CHC is an individual and oral, potentially malignant disorder according to the retrieved evidence. Prospective cohort studies to define the natural history of CHC and a consensus statement to clarify a proper set of diagnostic criteria are strongly needed. PROSPERO ID: CRD42022319572.Chronic hyperplastic candidiasis (CHC) is a prototypical oral lesion caused by chronic Candida infection. A major controversy surrounding CHC is whether this oral lesion owns malignant transformation (MT) potential. The aim of the present study was to evaluate current evidence on the MT of CHC and to determine the variables which have the greatest influence on cancer development. Bibliographical searches included PubMed, Embase, Web of Science, Scopus and LILACS. The cohort studies and case series used to investigate the MT of CHC were deemed suitable for inclusion. The quality of the enrolled studies was measured by the Joanna Briggs Institute scale. Moreover, we undertook subgroup analyses, assessed small study effects, and conducted sensitivity analyses. From 338 studies, nine were finally included for qualitative/quantitative analysis. The overall MT rate for CHC across all studies was 12.1% (95% confidential interval, 4.1-19.8%). Subgroup analysis showed that the MT rate increased when pooled analysis was restricted to poor quality studies. It remains complex to affirm whether CHC is an individual and oral, potentially malignant disorder according to the retrieved evidence. Prospective cohort studies to define the natural history of CHC and a consensus statement to clarify a proper set of diagnostic criteria are strongly needed. PROSPERO ID: CRD42022319572. Chronic hyperplastic candidiasis (CHC) is a prototypical oral lesion caused by chronic Candida infection. A major controversy surrounding CHC is whether this oral lesion owns malignant transformation (MT) potential. The aim of the present study was to evaluate current evidence on the MT of CHC and to determine the variables which have the greatest influence on cancer development. Bibliographical searches included PubMed, Embase, Web of Science, Scopus and LILACS. The cohort studies and case series used to investigate the MT of CHC were deemed suitable for inclusion. The quality of the enrolled studies was measured by the Joanna Briggs Institute scale. Moreover, we undertook subgroup analyses, assessed small study effects, and conducted sensitivity analyses. From 338 studies, nine were finally included for qualitative/quantitative analysis. The overall MT rate for CHC across all studies was 12.1% (95% confidential interval, 4.1–19.8%). Subgroup analysis showed that the MT rate increased when pooled analysis was restricted to poor quality studies. It remains complex to affirm whether CHC is an individual and oral, potentially malignant disorder according to the retrieved evidence. Prospective cohort studies to define the natural history of CHC and a consensus statement to clarify a proper set of diagnostic criteria are strongly needed. PROSPERO ID: CRD42022319572. Chronic hyperplastic candidiasis (CHC) is a prototypical oral lesion caused by chronic Candida infection. A major controversy surrounding CHC is whether this oral lesion owns malignant transformation (MT) potential. The aim of the present study was to evaluate current evidence on the MT of CHC and to determine the variables which have the greatest influence on cancer development. Bibliographical searches included PubMed, Embase, Web of Science, Scopus and LILACS. The cohort studies and case series used to investigate the MT of CHC were deemed suitable for inclusion. The quality of the enrolled studies was measured by the Joanna Briggs Institute scale. Moreover, we undertook subgroup analyses, assessed small study effects, and conducted sensitivity analyses. From 338 studies, nine were finally included for qualitative/quantitative analysis. The overall MT rate for CHC across all studies was 12.1% (95% confidential interval, 4.1–19.8%). Subgroup analysis showed that the MT rate increased when pooled analysis was restricted to poor quality studies. It remains complex to affirm whether CHC is an individual and oral, potentially malignant disorder according to the retrieved evidence. Prospective cohort studies to define the natural history of CHC and a consensus statement to clarify a proper set of diagnostic criteria are strongly needed. PROSPERO ID: CRD42022319572. |
| Author | Caponio, Vito Carlo Alberto Álvarez-Calderón-Iglesias, Óscar Pérez-Jardón, Alba Spirito, Francesca Chamorro-Petronacci, Cintia M. Gándara-Vila, Pilar Lo Muzio, Lorenzo Pérez-Sayáns, Mario Lorenzo-Pouso, Alejandro I. |
| AuthorAffiliation | 1 Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group), Faculty of Medicine and Dentistry, University of Santiago de Compostela, 15782 A Coruña, Spain 2 Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain 5 HM Hospitals Research Foundation, 28015 Madrid, Spain 4 Research, Health and Podiatry Group, Department of Health Sciences, Faculty of Nursing and Podiatry, University of A Coruña, 15008 A Coruña, Spain 3 Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy |
| AuthorAffiliation_xml | – name: 4 Research, Health and Podiatry Group, Department of Health Sciences, Faculty of Nursing and Podiatry, University of A Coruña, 15008 A Coruña, Spain – name: 5 HM Hospitals Research Foundation, 28015 Madrid, Spain – name: 1 Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group), Faculty of Medicine and Dentistry, University of Santiago de Compostela, 15782 A Coruña, Spain – name: 2 Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain – name: 3 Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy |
| Author_xml | – sequence: 1 givenname: Alejandro I. orcidid: 0000-0002-9180-4703 surname: Lorenzo-Pouso fullname: Lorenzo-Pouso, Alejandro I. – sequence: 2 givenname: Alba orcidid: 0000-0001-5174-8922 surname: Pérez-Jardón fullname: Pérez-Jardón, Alba – sequence: 3 givenname: Vito Carlo Alberto orcidid: 0000-0001-5080-5921 surname: Caponio fullname: Caponio, Vito Carlo Alberto – sequence: 4 givenname: Francesca orcidid: 0000-0002-8364-2425 surname: Spirito fullname: Spirito, Francesca – sequence: 5 givenname: Cintia M. orcidid: 0000-0002-5637-9908 surname: Chamorro-Petronacci fullname: Chamorro-Petronacci, Cintia M. – sequence: 6 givenname: Óscar orcidid: 0000-0002-1104-6894 surname: Álvarez-Calderón-Iglesias fullname: Álvarez-Calderón-Iglesias, Óscar – sequence: 7 givenname: Pilar surname: Gándara-Vila fullname: Gándara-Vila, Pilar – sequence: 8 givenname: Lorenzo orcidid: 0000-0003-4633-4893 surname: Lo Muzio fullname: Lo Muzio, Lorenzo – sequence: 9 givenname: Mario orcidid: 0000-0003-2196-9868 surname: Pérez-Sayáns fullname: Pérez-Sayáns, Mario |
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| Snippet | Chronic hyperplastic candidiasis (CHC) is a prototypical oral lesion caused by chronic Candida infection. A major controversy surrounding CHC is whether this... Chronic hyperplastic candidiasis (CHC) is a prototypical oral lesion caused by chronic Candida infection. A major controversy surrounding CHC is whether this... |
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| SubjectTerms | Candida Candidiasis chronic hyperplastic candidiasis Chronic infection Content analysis Genetic transformation Infections malignant transformation Meta-analysis mouth neoplasm Oral cancer Response rates Review Sensitivity analysis Systematic review Vitamin deficiency |
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| Title | Oral Chronic Hyperplastic Candidiasis and Its Potential Risk of Malignant Transformation: A Systematic Review and Prevalence Meta-Analysis |
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