The effect of stone-wool on rat lungs and on the primary culture of rat alveolar macrophages and type II pneumocytes
The effect of stone‐wool has been studied in both in vivo long term sequential and in vitro methods in male Sprague‐Dawley rats. Stone‐wool was administered by single intratracheal instillation and the lungs were examined after 1, 3 and 6 months of exposure by morphological methods. UICC crocidolite...
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Published in | Journal of applied toxicology Vol. 26; no. 1; pp. 16 - 24 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Chichester, UK
John Wiley & Sons, Ltd
01.01.2006
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Abstract | The effect of stone‐wool has been studied in both in vivo long term sequential and in vitro methods in male Sprague‐Dawley rats. Stone‐wool was administered by single intratracheal instillation and the lungs were examined after 1, 3 and 6 months of exposure by morphological methods. UICC crocidolite was applied as a positive control. In addition, the effects of both fibres were examined in primary cultures of alveolar macrophages (AM) and type II pneumocytes (T2) by morphological, biochemical and immunological methods. By the end of 6 months stone‐wool induced moderate pulmonary interstitial inflammation and fibrosis without progression, whereas crocidolite induced progressive interstitial inflammation and fibrosis as a function of time. Although stone‐wool inhibited phagocytosis, it did not induce serious membrane damage to the cells examined and did not destroy their ultrastructure. It significantly reduced the activity of Cu,Zn/superoxide dismutase (SOD) and alkaline phosphatase (AP) in alveolar macrophages and significantly decreased the activity of AP and γ‐glutamyl transpeptidase (GGT) in type II pneumocytes. Crocidolite, on the other hand, decreased the activity of all enzymes (glutathione peroxidase, GSH‐Px; glutathione reductase, GSH‐Rd) of glutathione metabolism as well as alkaline phosphatase in alveolar macrophages. It decreased the activity of all enzymes in type II pneumocytes, except for Cu,Zn/SOD. On exposure to stone‐wool, the production of inflammatory proteins, macrophage chemoattractant protein‐1 (MCP‐1) and macrophage inhibitory protein‐1α (MIP‐1α) increased in both cultured cells but did not reach the level induced by crocidolite. Our results suggested that stone‐wool is less toxic than crocidolite. Whether it is carcinogenic or not, is still an open question. Copyright © 2005 John Wiley & Sons, Ltd. |
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AbstractList | The effect of stone-wool in both in vivo long term sequential and in vitro methods in male Sprague-Dawley rats is investigated. The stone-wool is administered by single intratracheal instillation and the lungs are examined after 1, 3 and 6 months of exposure by morphological methods. UICC crocidolite is applied as a positive control. The effects of both fibers are examined in primary cultures of alveolar macrophages (AM) and type II pneumocytes (T2) by morphological, biochemical and immunological methods. The stone-wool induced moderate pulmonary interstitial inflammation and fibrosis without progression, whereas crocidolite induced progressive interstitial inflammation and fibrosis as a function of time. It is found that the stone-wool is less toxic than crocidolite. The effect of stone-wool has been studied in both in vivo long term sequential and in vitro methods in male Sprague-Dawley rats. Stone-wool was administered by single intratracheal instillation and the lungs were examined after 1, 3 and 6 months of exposure by morphological methods. UICC crocidolite was applied as a positive control. In addition, the effects of both fibres were examined in primary cultures of alveolar macrophages (AM) and type II pneumocytes (T2) by morphological, biochemical and immunological methods. By the end of 6 months stone-wool induced moderate pulmonary interstitial inflammation and fibrosis without progression, whereas crocidolite induced progressive interstitial inflammation and fibrosis as a function of time. Although stone-wool inhibited phagocytosis, it did not induce serious membrane damage to the cells examined and did not destroy their ultrastructure. It significantly reduced the activity of Cu,Zn/superoxide dismutase (SOD) and alkaline phosphatase (AP) in alveolar macrophages and significantly decreased the activity of AP and gamma-glutamyl transpeptidase (GGT) in type II pneumocytes. Crocidolite, on the other hand, decreased the activity of all enzymes (glutathione peroxidase, GSH-Px; glutathione reductase, GSH-Rd) of glutathione metabolism as well as alkaline phosphatase in alveolar macrophages. It decreased the activity of all enzymes in type II pneumocytes, except for Cu,Zn/SOD. On exposure to stone-wool, the production of inflammatory proteins, macrophage chemoattractant protein-1 (MCP-1) and macrophage inhibitory protein-1alpha (MIP-1alpha) increased in both cultured cells but did not reach the level induced by crocidolite. Our results suggested that stone-wool is less toxic than crocidolite. Whether it is carcinogenic or not, is still an open question. The effect of stone-wool has been studied in both in vivo long term sequential and in vitro methods in male Sprague-Dawley rats. Stone-wool was administered by single intratracheal instillation and the lungs were examined after 1, 3 and 6 months of exposure by morphological methods. UICC crocidolite was applied as a positive control. In addition, the effects of both fibres were examined in primary cultures of alveolar macrophages (AM) and type II pneumocytes (T2) by morphological, biochemical and immunological methods. By the end of 6 months stone-wool induced moderate pulmonary interstitial inflammation and fibrosis without progression, whereas crocidolite induced progressive interstitial inflammation and fibrosis as a function of time. Although stone-wool inhibited phagocytosis, it did not induce serious membrane damage to the cells examined and did not destroy their ultrastructure. It significantly reduced the activity of Cu,Zn/eroxide dismutase (SOD) and alkaline phosphatase (AP) in alveolar macrophages and significantly decreased the activity of AP and -glutamyl transpeptidase (GGT) in type II pneumocytes. Crocidolite, on the other hand, decreased the activity of all enzymes (glutathione peroxidase, GSH-Px; glutathione reductase, GSH-Rd) of glutathione metabolism as well as alkaline phosphatase in alveolar macrophages. It decreased the activity of all enzymes in type II pneumocytes, except for Cu,Zn/SOD. On exposure to stone-wool, the production of inflammatory proteins, macrophage chemoattractant protein-1 (MCP-1) and macrophage inhibitory protein-1 (MIP-1) increased in both cultured cells but did not reach the level induced by crocidolite. Our results suggested that stone-wool is less toxic than crocidolite. Whether it is carcinogenic or not, is still an open question. The effect of stone‐wool has been studied in both in vivo long term sequential and in vitro methods in male Sprague‐Dawley rats. Stone‐wool was administered by single intratracheal instillation and the lungs were examined after 1, 3 and 6 months of exposure by morphological methods. UICC crocidolite was applied as a positive control. In addition, the effects of both fibres were examined in primary cultures of alveolar macrophages (AM) and type II pneumocytes (T2) by morphological, biochemical and immunological methods. By the end of 6 months stone‐wool induced moderate pulmonary interstitial inflammation and fibrosis without progression, whereas crocidolite induced progressive interstitial inflammation and fibrosis as a function of time. Although stone‐wool inhibited phagocytosis, it did not induce serious membrane damage to the cells examined and did not destroy their ultrastructure. It significantly reduced the activity of Cu,Zn/superoxide dismutase (SOD) and alkaline phosphatase (AP) in alveolar macrophages and significantly decreased the activity of AP and γ‐glutamyl transpeptidase (GGT) in type II pneumocytes. Crocidolite, on the other hand, decreased the activity of all enzymes (glutathione peroxidase, GSH‐Px; glutathione reductase, GSH‐Rd) of glutathione metabolism as well as alkaline phosphatase in alveolar macrophages. It decreased the activity of all enzymes in type II pneumocytes, except for Cu,Zn/SOD. On exposure to stone‐wool, the production of inflammatory proteins, macrophage chemoattractant protein‐1 (MCP‐1) and macrophage inhibitory protein‐1α (MIP‐1α) increased in both cultured cells but did not reach the level induced by crocidolite. Our results suggested that stone‐wool is less toxic than crocidolite. Whether it is carcinogenic or not, is still an open question. Copyright © 2005 John Wiley & Sons, Ltd. |
Author | Brozik, Márta Kováčiková, Zuzana Csík, Márta Tátrai, Erzsébet Six, Éva Dám, Annamária Drahos, Ágnes |
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Cites_doi | 10.4049/jimmunol.150.10.4561 10.1007/BF02714430 10.1183/09031936.99.13482099 10.1016/S0278-6915(99)00087-3 10.1034/j.1399-3003.2000.016003534.x 10.1126/science.2552581 10.1164/ajrccm.162.5.2003137 10.1016/S0300-483X(01)00418-8 10.1289/ehp.8456149 10.1164/ajrccm/138.5.1268 10.1007/PL00007600 10.1093/annhyg/41.inhaled_particles_VIII.213 10.3109/01902149209031711 10.1093/clinchem/15.2.124 10.1021/bi00596a023 10.1006/enrs.1997.3825 10.1146/annurev.bi.52.070183.003431 10.1165/ajrcmb.11.5.7946387 10.1016/0006-2952(94)90281-X 10.1165/ajrcmb.17.5.2753 |
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Keywords | Lung disease Lectin MCP-1 Rat Respiratory disease antioxidant system stone-wool Rodentia alveolar macrophages lectins EDXA Antioxidant Mineral fiber Respiratory system In vitro Vertebrata Mammalia Pulmonary fibrosis Animal MIP-1α Primary culture Macrophage pneumocytes |
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Snippet | The effect of stone‐wool has been studied in both in vivo long term sequential and in vitro methods in male Sprague‐Dawley rats. Stone‐wool was administered by... The effect of stone-wool has been studied in both in vivo long term sequential and in vitro methods in male Sprague-Dawley rats. Stone-wool was administered by... The effect of stone-wool in both in vivo long term sequential and in vitro methods in male Sprague-Dawley rats is investigated. The stone-wool is administered... |
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SubjectTerms | alveolar macrophages Animals antioxidant system Biological and medical sciences Cell Membrane - drug effects Cell Membrane - pathology Chemokine CCL2 - metabolism Chemokine CCL3 Chemokine CCL4 EDXA lectins Lung - drug effects Lung - enzymology Lung - pathology Lung - ultrastructure Lymph Nodes - drug effects Lymph Nodes - ultrastructure Macrophage Inflammatory Proteins - metabolism Macrophages, Alveolar - drug effects Macrophages, Alveolar - enzymology Macrophages, Alveolar - ultrastructure Male MCP-1 Medical sciences Microscopy, Electron, Scanning Microscopy, Electron, Transmission Mineral Fibers - toxicity MIP-1α pneumocytes Pneumology pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - pathology Rats Rats, Sprague-Dawley Respiratory system : syndromes and miscellaneous diseases stone-wool Toxicology |
Title | The effect of stone-wool on rat lungs and on the primary culture of rat alveolar macrophages and type II pneumocytes |
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