Stromal Cell-Derived Factor-1 Chemokine Gene Variant in Patients with Type 1 Diabetes and Autoimmune Thyroid Disease

• Published in: Annals of the New York Academy of Sciences Vol. 1037; no. 1; pp. 79 - 83
• Main Authors: KAWASAKI, EIJI, IDE, AKANE, ABIRU, NORIO, KOBAYASHI, MASAKAZU, FUKUSHIMA, TETSUYA, KUWAHARA, HIRONAGA, KITA, ATSUSHI, UOTANI, SHIGEO, YAMASAKI, HIRONORI, EGUCHI, KATSUMI
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2004
• Subjects: Autoimmune Diseases - complications; Autoimmune Diseases - genetics; autoimmune thyroid disease; Case-Control Studies; Chemokine CXCL12; Chemokines, CXC - genetics; Chemokines, CXC - metabolism; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - metabolism; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; genetics; Humans; Male; polymorphism; Polymorphism, Genetic; SDF-1; SNPs; Thyroid Diseases - complications; Thyroid Diseases - genetics; type 1 diabetes
• ISSN: 0077-8923; 1749-6632
• DOI: 10.1196/annals.1337.012

: Type 1 diabetes is a heterogenous autoimmune disease and is frequently associated with other organ‐specific autoimmune diseases, including autoimmune thyroid disease (AITD). Type 1 diabetic patients with AITD are known to have clinical and immunological features distinct from patients without AITD. This study investigated whether stromal cell‐derived factor (SDF)‐1 gene polymorphism is associated with susceptibility to type 1 diabetes and AITD. SDF‐1 is a powerful chemokine that upregulates T‐cell migration and activation, and the gene for SDF‐1 is located near type 1 diabetes susceptibility locus IDDM10. The SDF1‐3′A variant (801 G to A in the 3′‐untranslated region) was determined by the PCR‐RFLP technique in 54 type 1 diabetic patients with AITD, 75 type 1 diabetic patients without AITD, 137 nondiabetic patients with AITD, and 106 healthy subjects in a case‐control study. No significant differences on the allele and genotype frequencies of the SDF1 gene polymorphism were found, not only in type 1 diabetic patients with AITD compared with normal controls but also between nondiabetic patients with AITD and healthy control subjects. These results suggest that the SDF1‐3′A variant is not associated with genetic susceptibility to type 1 diabetic patients and AITD.