Effect of Different Curcuminoid Supplement Dosages on Total In Vivo Antioxidant Capacity and Cholesterol Levels of Healthy Human Subjects

• Published in: Phytotherapy research Vol. 25; no. 11; pp. 1721 - 1726
• Main Authors: Pungcharoenkul, Kanit, Thongnopnua, Phensri
• Format: Journal Article
• Language: English
• Published: Chichester Blackwell Publishing Ltd 01.11.2011; Wiley; Wiley Subscription Services, Inc
• Subjects: absorbance; administration & dosage; alpha-Tocopherol; alpha-Tocopherol - blood; antioxidant; antioxidant activity; antioxidants; Antioxidants - administration & dosage; Biological and medical sciences; blood; cholesterol; Cholesterol - blood; curcumin; Curcumin - administration & dosage; Dietary Supplements; Female; General pharmacology; Humans; Male; Medical sciences; oxygen; oxygen radical absorbance capacity (ORAC) assay; people; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Rosa; total antioxidant capacity; triacylglycerols; Triglycerides; Triglycerides - blood; vitamin E; Vitamin E - administration & dosage; α-tocopherol; Human; Oxygen; Healthy subject; Tyrosine kinase inhibitor; Pharmacognosy; Vitamin; Lipids; α-Tocopherol; Antioxidant; Cholesterol; Medicinal plant; In vivo; Organic pigment; total antioxidant capacity; Plant origin; oxygen radical absorbance capacity (ORAC) assay; Curcumin; antioxidant: cholesterol
• ISSN: 0951-418X; 1099-1573; 1099-1573
• DOI: 10.1002/ptr.3608

The impact of consuming curcuminoids containing curcumin at 500 mg/day and 6 g/day for 7 days on plasma antioxidant capacity and serum cholesterol level were determined by using vitamin E 200 IU/day consumption as a comparison. Group A and group B subjects consumed 500 mg and 6 g curcumin, respectively, but group C subjects consumed vitamin E 200 IU. By using the oxygen radical absorbance capacity (ORAC) assay, it was found that plasma antioxidant capacity of group A rose from a baseline of 13% to 24% on day 1 and day 7, as against a 19–20% increase for group B. Serum cholesterol and triglyceride levels were significantly decreased after curcumin treatment at 500 mg/day. By consuming vitamin E, both ORAC values and plasma α‐tocopherol concentrations were significantly increased, but only very slight responses on serum cholesterol or triglyceride levels were observed. It is therefore suggested that curcumin supplement would not be appropriate for healthy people except for reducing serum cholesterol or triglyceride levels. The dosage of a daily curcumin supplement at 500 mg is more effective than 6 g, although vitamin E is also considered to be an effective antioxidant supplement. Copyright © 2011 John Wiley & Sons, Ltd.