Human SIRT1: A potential biomarker for tumorigenesis?

Accumulating body of evidence reveals that hSIRT1, an NAD +-dependent protein deacetylase, is involved in regulating numerous biological processes. Therefore cellular functions of hSIRT1 are highly pleiotropic. The integrated hypothetical mechanisms of hSIRT1 action contributing to regulating cellul...

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Bibliographic Details
Published inCell biology international Vol. 31; no. 6; pp. 636 - 637
Main Author Lim, Chang-Su
Format Journal Article
LanguageEnglish
Published Oxford, UK Elsevier Ltd 01.06.2007
Blackwell Publishing Ltd
Subjects
Biomarkers, Tumor - metabolism
DNA Damage
Humans
Kruppel-Like Transcription Factors - metabolism
Models, Biological
Protein Binding
Sirtuin 1
Sirtuins - metabolism
Tumor Suppressor Protein p53 - metabolism
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Summary:Accumulating body of evidence reveals that hSIRT1, an NAD +-dependent protein deacetylase, is involved in regulating numerous biological processes. Therefore cellular functions of hSIRT1 are highly pleiotropic. The integrated hypothetical mechanisms of hSIRT1 action contributing to regulating cellular senescence and longevity have been proposed. Based on recent evidence, I propose that hSIRT1 is a potential biomarker for tumorigenesis.
Bibliography:istex:056AC1EC7CE0890BE7477DC316EE214788E1C0B6
ArticleID:CBIN1878
ark:/67375/WNG-22FQM6C6-3
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1065-6995
1095-8355
DOI:10.1016/j.cellbi.2006.11.003