Human SIRT1: A potential biomarker for tumorigenesis?
Accumulating body of evidence reveals that hSIRT1, an NAD +-dependent protein deacetylase, is involved in regulating numerous biological processes. Therefore cellular functions of hSIRT1 are highly pleiotropic. The integrated hypothetical mechanisms of hSIRT1 action contributing to regulating cellul...
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Published in | Cell biology international Vol. 31; no. 6; pp. 636 - 637 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Elsevier Ltd
01.06.2007
Blackwell Publishing Ltd |
Subjects | |
Online Access | Get full text |
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Summary: | Accumulating body of evidence reveals that hSIRT1, an NAD
+-dependent protein deacetylase, is involved in regulating numerous biological processes. Therefore cellular functions of hSIRT1 are highly pleiotropic. The integrated hypothetical mechanisms of hSIRT1 action contributing to regulating cellular senescence and longevity have been proposed. Based on recent evidence, I propose that hSIRT1 is a potential biomarker for tumorigenesis. |
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Bibliography: | istex:056AC1EC7CE0890BE7477DC316EE214788E1C0B6 ArticleID:CBIN1878 ark:/67375/WNG-22FQM6C6-3 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1065-6995 1095-8355 |
DOI: | 10.1016/j.cellbi.2006.11.003 |