Preservation of red cell antigens during storage of blood with different anticoagulants

A major concern when storing blood is that the antigens of the red cells will lose some of their reactivity in vitro. As part of a study of blood stored in newer anticoagulants, we tested the persistence of the ABO, Rh, Lewis, and P antigens. Blood was stored for 21 to 35 days in several anticoagula...

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Bibliographic Details
Published inTransfusion (Philadelphia, Pa.) Vol. 24; no. 6; p. 499
Main Authors Myhre, B A, Demaniew, S, Nelson, E J
Format Journal Article
LanguageEnglish
Published United States 01.11.1984
Subjects
Anticoagulants - pharmacology
Blood Preservation
Erythrocyte Membrane - drug effects
Erythrocytes - immunology
Humans
Plasticizers
Time Factors
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Summary:A major concern when storing blood is that the antigens of the red cells will lose some of their reactivity in vitro. As part of a study of blood stored in newer anticoagulants, we tested the persistence of the ABO, Rh, Lewis, and P antigens. Blood was stored for 21 to 35 days in several anticoagulant-preservative systems, such as citrate-phosphate-dextrose and several additive solutions, while using bags of polyvinyl chloride plasticized with di(2-ethyl hexyl) phthalate or tri (2-ethyl hexyl) trimellitate. No significant loss of antigenicity occurred in the ABO and Rh systems, but antigens in the Lewis and P systems lost some reactivity during storage.
ISSN:0041-1132
DOI:10.1046/j.1537-2995.1984.24685066809.x