Electrochemical Detection of Single A-G Mismatch Using Biosensing Surface Based on Gold Nanoparticles
The study of small drug molecules interacting with nucleic acids is an area of intense research that has particular relevance in our understanding of relative mechanism in chemotherapeutic applications and the association between genetics (including sequence variation) and drug response. In this con...
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Published in | Genomics, proteomics & bioinformatics Vol. 3; no. 1; pp. 47 - 51 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
2005
Chien-Shiung Wu Laboratory, National Lab of Molecular and Biomolecular Electronics, Department of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The study of small drug molecules interacting with nucleic acids is an area of intense research that has particular relevance in our understanding of relative mechanism in chemotherapeutic applications and the association between genetics (including sequence variation) and drug response. In this contribution, we demonstrate how the sequence-specific binding of an anticancer drug Dacarbazine (DTIC) to single base (A-G) mismatch could be sensitively detected by combining electrochemical detection with biosensing surface based on gold nanoparticles. |
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Bibliography: | 11-4926/Q O646 R979.1 single base mismatch, DTIC, electrochemistry, gold nanoparticles, biosensor |
ISSN: | 1672-0229 2210-3244 |
DOI: | 10.1016/S1672-0229(05)03007-X |