Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition

• Published in: Advanced materials (Weinheim) Vol. 24; no. 48; pp. 6484 - 6489
• Main Authors: Liu, Shao Qiong, Yang, Chuan, Huang, Yuan, Ding, Xin, Li, Yan, Fan, Wei Min, Hedrick, James L., Yang, Yi-Yan
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 18.12.2012; WILEY‐VCH Verlag
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; antifouling; Biofouling - prevention & control; broad spectrum antimicrobial; Candida albicans - drug effects; cationic polycarbonates; Dose-Response Relationship, Drug; Escherichia coli - drug effects; hydrogels; Hydrogels - chemical synthesis; Hydrogels - chemistry; Hydrogels - pharmacology; michael addition; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Polycarboxylate Cement - chemical synthesis; Polycarboxylate Cement - chemistry; Polycarboxylate Cement - pharmacology; Polyethylene Glycols - chemical synthesis; Polyethylene Glycols - chemistry; Polyethylene Glycols - pharmacology; Staphylococcus aureus - drug effects; Structure-Activity Relationship; tunable mechanical properties
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.201202225

A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad‐spectrum antimicrobial activities against various clinically isolated multidrug‐resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.