Is a history of gestational diabetes related to risk factors for coronary heart disease?

• Published in: Research in nursing & health Vol. 32; no. 3; pp. 298 - 306
• Main Authors: King, Kathleen B., Gerich, John E., Guzick, David S., King, Kathleen U., McDermott, Michael P.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2009; Wiley; Wiley Subscription Services, Inc
• Subjects: Adult; Biological and medical sciences; Cardiology. Vascular system; Cardiovascular disease; cardiovascular risk; Case-Control Studies; Chi-Square Distribution; Cholesterol; Cholesterol - blood; Cholesterol, HDL - blood; Coronary Disease - blood; Coronary Disease - epidemiology; Coronary Disease - etiology; Coronary diseases; Coronary heart disease; Diabetes; Diabetes Complications - blood; Diabetes Complications - complications; Diabetes Complications - epidemiology; Diabetes Mellitus, Type 2 - etiology; Diabetes, Gestational - blood; Diabetes, Gestational - epidemiology; Diabetes, Gestational - etiology; Distant; Female; gestational diabetes; Gestational diabetes mellitus; Glucose; Heart; Heart diseases; Humans; Logistic Models; Medical sciences; Middle Aged; Miscellaneous; Multivariate Analysis; Nursing; Obesity - complications; Prediabetic State - etiology; Pregnancy; Public health. Hygiene; Public health. Hygiene-occupational medicine; Risk Assessment; Risk Factors; Time Factors; Triglycerides - blood; Women; Risk factor; Cardiovascular risk; Cardiovascular disease; Gestational diabetes; History; Coronary heart disease; Case history; diabetes; Public health
• ISSN: 0160-6891; 1098-240X
• DOI: 10.1002/nur.20325

Coronary heart disease (CHD) risk in 20 non‐diabetic women with and 20 without a distant history of gestational diabetes (hGDM), matched on age, body mass index, and time since GDM‐affected pregnancy, was compared in a case control study. Women with an hGDM had lower high‐density lipoprotein cholesterol (HDL‐c), p = .02, and higher triglycerides, p ≤ .001, versus controls. The combination of high triglycerides and low HDL‐c occurred in 25% of hGDM cases versus 0% of controls, p ≤ .01. Two‐hour post‐load glucose indicated that 45% of hGDM cases were pre‐diabetic versus 20% of controls, p ≤ .05. Non‐diabetic women with a distant hGDM are at increased risk for DM and may be at increased risk for CHD. © 2009 Wiley Periodicals, Inc. Res Nurs Health 32:298–306, 2009