Vitamin D may alleviate pre‐eclampsia by modulating the ferroptosis signalling pathway: A hypothesis based on recent literature
Ferroptosis is a novel form of regulated cell death typically characterized by non‐apoptotic, iron‐dependent, and reactive accumulation of oxygen species. Recent studies have found that ferroptosis plays an important role in the pathophysiology of pre‐eclampsia (PE). In order to find potential thera...
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| Published in | Journal of cellular and molecular medicine Vol. 27; no. 14; pp. 1923 - 1927 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
John Wiley & Sons, Inc
01.07.2023
John Wiley and Sons Inc |
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| Abstract | Ferroptosis is a novel form of regulated cell death typically characterized by non‐apoptotic, iron‐dependent, and reactive accumulation of oxygen species. Recent studies have found that ferroptosis plays an important role in the pathophysiology of pre‐eclampsia (PE). In order to find potential therapeutic targets for ferroptosis intervention and better prevent the occurrence and progression of PE, the signalling pathways that regulate ferroptosis need to be identified. In this article, we review the role of vitamin D in PE and the role of ferroptosis in PE. Based on recent literature, we propose the scientific hypothesis that vitamin D can alleviate preeclampsia by modulating the ferroptosis signalling pathway. The aim of this review is to understand the regulatory pathways of ferroptosis in PE and to identify potential therapeutic targets. |
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| AbstractList | Ferroptosis is a novel form of regulated cell death typically characterized by non-apoptotic, iron-dependent, and reactive accumulation of oxygen species. Recent studies have found that ferroptosis plays an important role in the pathophysiology of pre-eclampsia (PE). In order to find potential therapeutic targets for ferroptosis intervention and better prevent the occurrence and progression of PE, the signalling pathways that regulate ferroptosis need to be identified. In this article, we review the role of vitamin D in PE and the role of ferroptosis in PE. Based on recent literature, we propose the scientific hypothesis that vitamin D can alleviate preeclampsia by modulating the ferroptosis signalling pathway. The aim of this review is to understand the regulatory pathways of ferroptosis in PE and to identify potential therapeutic targets. Ferroptosis is a novel form of regulated cell death typically characterized by non-apoptotic, iron-dependent, and reactive accumulation of oxygen species. Recent studies have found that ferroptosis plays an important role in the pathophysiology of pre-eclampsia (PE). In order to find potential therapeutic targets for ferroptosis intervention and better prevent the occurrence and progression of PE, the signalling pathways that regulate ferroptosis need to be identified. In this article, we review the role of vitamin D in PE and the role of ferroptosis in PE. Based on recent literature, we propose the scientific hypothesis that vitamin D can alleviate preeclampsia by modulating the ferroptosis signalling pathway. The aim of this review is to understand the regulatory pathways of ferroptosis in PE and to identify potential therapeutic targets.Ferroptosis is a novel form of regulated cell death typically characterized by non-apoptotic, iron-dependent, and reactive accumulation of oxygen species. Recent studies have found that ferroptosis plays an important role in the pathophysiology of pre-eclampsia (PE). In order to find potential therapeutic targets for ferroptosis intervention and better prevent the occurrence and progression of PE, the signalling pathways that regulate ferroptosis need to be identified. In this article, we review the role of vitamin D in PE and the role of ferroptosis in PE. Based on recent literature, we propose the scientific hypothesis that vitamin D can alleviate preeclampsia by modulating the ferroptosis signalling pathway. The aim of this review is to understand the regulatory pathways of ferroptosis in PE and to identify potential therapeutic targets. |
| Author | He, Lian‐Ping Su, Hua‐Qin Li, Cui‐Ping |
| AuthorAffiliation | 1 School of Medicine Taizhou University Jiaojiang Zhejiang China 2 Taizhou Jiaojiang District Xiachen Street Community Health Service Centre Jiaojiang Zhejiang China |
| AuthorAffiliation_xml | – name: 1 School of Medicine Taizhou University Jiaojiang Zhejiang China – name: 2 Taizhou Jiaojiang District Xiachen Street Community Health Service Centre Jiaojiang Zhejiang China |
| Author_xml | – sequence: 1 givenname: Cui‐Ping orcidid: 0000-0002-9410-1835 surname: Li fullname: Li, Cui‐Ping organization: Taizhou University – sequence: 2 givenname: Hua‐Qin orcidid: 0000-0002-7352-4388 surname: Su fullname: Su, Hua‐Qin organization: Taizhou Jiaojiang District Xiachen Street Community Health Service Centre – sequence: 3 givenname: Lian‐Ping orcidid: 0000-0002-9627-5599 surname: He fullname: He, Lian‐Ping email: lianpinghe@tzc.edu.cn organization: Taizhou University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37099247$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.2174/1566524022666220607163232 10.1016/j.anclin.2016.09.009 10.1016/j.ejogrb.2013.05.005 10.1186/s12884-023-05363-5 10.1371/journal.pone.0281234 10.1016/j.exger.2022.111836 10.1128/spectrum.01121-22 10.12998/wjcc.v10.i16.5515 10.1080/14767058.2019.1566311 10.1111/jcmm.17701 10.1016/0002-9378(88)90090-7 10.1080/09513590.2022.2146089 10.31083/j.ceog5003066 10.1111/jch.14606 10.1152/ajpcell.00411.2022 10.1007/s12011-023-03556-9 10.3390/ijms23169395 10.1155/2022/5953562 10.3390/cells12010099 10.1111/1471-0528.17222 10.1016/j.cell.2012.03.042 10.1136/bmjopen-2022-064736 10.1007/s12020-022-03272-9 10.1038/s41430-022-01232-0 10.1016/j.preghy.2021.09.008 10.1016/j.freeradbiomed.2021.08.231 10.3390/antiox11071282 |
| ContentType | Journal Article |
| Copyright | 2023 The Authors. published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Snippet | Ferroptosis is a novel form of regulated cell death typically characterized by non‐apoptotic, iron‐dependent, and reactive accumulation of oxygen species.... Ferroptosis is a novel form of regulated cell death typically characterized by non-apoptotic, iron-dependent, and reactive accumulation of oxygen species.... |
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| StartPage | 1923 |
| SubjectTerms | Apoptosis Bioenergetics Blood pressure Cell death Conflicts of interest Disease Female Ferroptosis Genes Homeostasis Humans Hypertension Hypotheses Iron Iron - metabolism Lipids Metabolism Morphology Oxidative stress Pathogenesis Polymorphism Pre-eclampsia Pre-Eclampsia - drug therapy Preeclampsia Pregnancy Reactive Oxygen Species - metabolism Review Reviews Signal transduction signalling pathways Systematic review Therapeutic applications Therapeutic targets Vitamin D Vitamin D - pharmacology Vitamin deficiency Vitamins Womens health |
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| Title | Vitamin D may alleviate pre‐eclampsia by modulating the ferroptosis signalling pathway: A hypothesis based on recent literature |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjcmm.17754 https://www.ncbi.nlm.nih.gov/pubmed/37099247 https://www.proquest.com/docview/2836159210 https://www.proquest.com/docview/2806457667 https://pubmed.ncbi.nlm.nih.gov/PMC10339082 |
| Volume | 27 |
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