Vitamin D may alleviate pre‐eclampsia by modulating the ferroptosis signalling pathway: A hypothesis based on recent literature

• Published in: Journal of cellular and molecular medicine Vol. 27; no. 14; pp. 1923 - 1927
• Main Authors: Li, Cui‐Ping, Su, Hua‐Qin, He, Lian‐Ping
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.07.2023; John Wiley and Sons Inc
• Subjects: Apoptosis; Bioenergetics; Blood pressure; Cell death; Conflicts of interest; Disease; Female; Ferroptosis; Genes; Homeostasis; Humans; Hypertension; Hypotheses; Iron; Iron - metabolism; Lipids; Metabolism; Morphology; Oxidative stress; Pathogenesis; Polymorphism; Pre-eclampsia; Pre-Eclampsia - drug therapy; Preeclampsia; Pregnancy; Reactive Oxygen Species - metabolism; Review; Reviews; Signal transduction; signalling pathways; Systematic review; Therapeutic applications; Therapeutic targets; Vitamin D; Vitamin D - pharmacology; Vitamin deficiency; Vitamins; Womens health; signalling pathways; pre-eclampsia; ferroptosis
• ISSN: 1582-1838; 1582-4934; 1582-4934
• DOI: 10.1111/jcmm.17754

Ferroptosis is a novel form of regulated cell death typically characterized by non‐apoptotic, iron‐dependent, and reactive accumulation of oxygen species. Recent studies have found that ferroptosis plays an important role in the pathophysiology of pre‐eclampsia (PE). In order to find potential therapeutic targets for ferroptosis intervention and better prevent the occurrence and progression of PE, the signalling pathways that regulate ferroptosis need to be identified. In this article, we review the role of vitamin D in PE and the role of ferroptosis in PE. Based on recent literature, we propose the scientific hypothesis that vitamin D can alleviate preeclampsia by modulating the ferroptosis signalling pathway. The aim of this review is to understand the regulatory pathways of ferroptosis in PE and to identify potential therapeutic targets.