Biomedical applications of degradable polyphosphazenes

• Published in: Biotechnology and bioengineering Vol. 52; no. 1; pp. 102 - 108
• Main Authors: Schacht, Etienne, Vandorpe, Joke, Dejardin, Stéphane, Lemmouchi, Yahia, Seymour, Leonard
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 05.10.1996; Wiley
• Subjects: biodegradation; Biological and medical sciences; drug delivery; General pharmacology; Medical sciences; mitomycin C; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; polyphosphazenes; Antineoplastic agent; Mitomycin; Pharmaceutical technology; Implant; Support; Biodegradability; In vitro; Phosphazene polymer; Degradation; Ester; In vivo; Side chain; Aminoacid; Preparation; Dosage form; Chemical synthesis
• ISSN: 0006-3592; 1097-0290
• DOI: 10.1002/(SICI)1097-0290(19961005)52:1<102::AID-BIT10>3.0.CO;2-Q

This article describes the synthesis of biodegradable polyphosphazenes. The rate of degradation can be varied in a controllable manner by the introduction of hydrolysis‐sensitive amino acid ester side groups or by blending of polymers. Biodegradable polyphosphazenes can be used for the preparation of drug‐containing implants and this is illustrated for devices containing the cytostatic agent mitomycin C. This article reviews data about the degradation characteristics of poly[(amino acid ester)phosphazene] derivatives that have been discussed previously. Some new data about MMC‐containing poly[(organo)phosphazene] devices are discussed as well. © 1996 John Wiley & Sons, Inc.