Reproducibility of Cardiac Multifrequency MR Elastography in Assessing Left Ventricular Stiffness and Viscosity
Background Cardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical challenges, mainly synchronization with cardiac cycle, breathing, and external harmonic stimulation. Purpose To determine the reproducibility of in viv...
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| Published in | Journal of magnetic resonance imaging Vol. 61; no. 5; pp. 2146 - 2154 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken, USA
John Wiley & Sons, Inc
01.05.2025
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1053-1807 1522-2586 1522-2586 |
| DOI | 10.1002/jmri.29640 |
Cover
| Abstract | Background
Cardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical challenges, mainly synchronization with cardiac cycle, breathing, and external harmonic stimulation.
Purpose
To determine the reproducibility of in vivo cardiac multifrequency MRE (MMRE) for assessing diastolic left ventricular (LV) stiffness and viscosity.
Study Type
Prospective.
Subjects
This single‐center study included a total of 28 participants (mean age, 56.6 ± 23.0 years; 16 male) consisting of randomly selected healthy participants (mean age, 44.6 ± 20.1 years; 9 male) and patients with aortic stenosis (mean age, 78.3 ± 3.8 years; 7 male).
Field Strength/Sequence
3 T, 3D multifrequency MRE with a single‐shot spin‐echo planar imaging sequence.
Assessment
Each participant underwent two cardiac MMRE examinations on the same day. Full 3D wave fields were acquired in diastole at frequencies of 80, 90, and 100 Hz during a total of three breath‐holds. Shear wave speed (SWS) and penetration rate (PR) were reconstructed as a surrogate for tissue stiffness and inverse viscous loss. Epicardial and endocardial ROIs were manually drawn by two independent readers to segment the LV myocardium.
Statistical Tests
Shapiro–Wilk test, Bland–Altman analysis and intraclass correlation coefficient (ICC). P‐value <0.05 were considered statistically significant.
Results
Bland–Altman analyses and intraclass correlation coefficients (ICC = 0.96 for myocardial stiffness and ICC = 0.93 for viscosity) indicated near‐perfect test–retest repeatability among examinations on the same day. The mean SWS for scan and re‐scan diastolic LV myocardium were 2.42 ± 0.24 m/s and 2.39 ± 0.23 m/s; the mean PR were 1.24 ± 0.17 m/s and 1.22 ± 0.14 m/s. Inter‐reader variability showed good to excellent agreement for myocardial stiffness (ICC = 0.92) and viscosity (ICC = 0.85).
Data Conclusion
Cardiac MMRE is a promising and reproducible method for noninvasive assessment of diastolic LV stiffness and viscosity.
Level of Evidence
2
Technical Efficacy
1 |
|---|---|
| AbstractList | BackgroundCardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical challenges, mainly synchronization with cardiac cycle, breathing, and external harmonic stimulation.PurposeTo determine the reproducibility of in vivo cardiac multifrequency MRE (MMRE) for assessing diastolic left ventricular (LV) stiffness and viscosity.Study TypeProspective.SubjectsThis single‐center study included a total of 28 participants (mean age, 56.6 ± 23.0 years; 16 male) consisting of randomly selected healthy participants (mean age, 44.6 ± 20.1 years; 9 male) and patients with aortic stenosis (mean age, 78.3 ± 3.8 years; 7 male).Field Strength/Sequence3 T, 3D multifrequency MRE with a single‐shot spin‐echo planar imaging sequence.AssessmentEach participant underwent two cardiac MMRE examinations on the same day. Full 3D wave fields were acquired in diastole at frequencies of 80, 90, and 100 Hz during a total of three breath‐holds. Shear wave speed (SWS) and penetration rate (PR) were reconstructed as a surrogate for tissue stiffness and inverse viscous loss. Epicardial and endocardial ROIs were manually drawn by two independent readers to segment the LV myocardium.Statistical TestsShapiro–Wilk test, Bland–Altman analysis and intraclass correlation coefficient (ICC). P‐value <0.05 were considered statistically significant.ResultsBland–Altman analyses and intraclass correlation coefficients (ICC = 0.96 for myocardial stiffness and ICC = 0.93 for viscosity) indicated near‐perfect test–retest repeatability among examinations on the same day. The mean SWS for scan and re‐scan diastolic LV myocardium were 2.42 ± 0.24 m/s and 2.39 ± 0.23 m/s; the mean PR were 1.24 ± 0.17 m/s and 1.22 ± 0.14 m/s. Inter‐reader variability showed good to excellent agreement for myocardial stiffness (ICC = 0.92) and viscosity (ICC = 0.85).Data ConclusionCardiac MMRE is a promising and reproducible method for noninvasive assessment of diastolic LV stiffness and viscosity.Level of Evidence2Technical Efficacy1 Cardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical challenges, mainly synchronization with cardiac cycle, breathing, and external harmonic stimulation. To determine the reproducibility of in vivo cardiac multifrequency MRE (MMRE) for assessing diastolic left ventricular (LV) stiffness and viscosity. Prospective. This single-center study included a total of 28 participants (mean age, 56.6 ± 23.0 years; 16 male) consisting of randomly selected healthy participants (mean age, 44.6 ± 20.1 years; 9 male) and patients with aortic stenosis (mean age, 78.3 ± 3.8 years; 7 male). 3 T, 3D multifrequency MRE with a single-shot spin-echo planar imaging sequence. Each participant underwent two cardiac MMRE examinations on the same day. Full 3D wave fields were acquired in diastole at frequencies of 80, 90, and 100 Hz during a total of three breath-holds. Shear wave speed (SWS) and penetration rate (PR) were reconstructed as a surrogate for tissue stiffness and inverse viscous loss. Epicardial and endocardial ROIs were manually drawn by two independent readers to segment the LV myocardium. Shapiro-Wilk test, Bland-Altman analysis and intraclass correlation coefficient (ICC). P-value <0.05 were considered statistically significant. Bland-Altman analyses and intraclass correlation coefficients (ICC = 0.96 for myocardial stiffness and ICC = 0.93 for viscosity) indicated near-perfect test-retest repeatability among examinations on the same day. The mean SWS for scan and re-scan diastolic LV myocardium were 2.42 ± 0.24 m/s and 2.39 ± 0.23 m/s; the mean PR were 1.24 ± 0.17 m/s and 1.22 ± 0.14 m/s. Inter-reader variability showed good to excellent agreement for myocardial stiffness (ICC = 0.92) and viscosity (ICC = 0.85). Cardiac MMRE is a promising and reproducible method for noninvasive assessment of diastolic LV stiffness and viscosity. 2 TECHNICAL EFFICACY: 1. Cardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical challenges, mainly synchronization with cardiac cycle, breathing, and external harmonic stimulation.BACKGROUNDCardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical challenges, mainly synchronization with cardiac cycle, breathing, and external harmonic stimulation.To determine the reproducibility of in vivo cardiac multifrequency MRE (MMRE) for assessing diastolic left ventricular (LV) stiffness and viscosity.PURPOSETo determine the reproducibility of in vivo cardiac multifrequency MRE (MMRE) for assessing diastolic left ventricular (LV) stiffness and viscosity.Prospective.STUDY TYPEProspective.This single-center study included a total of 28 participants (mean age, 56.6 ± 23.0 years; 16 male) consisting of randomly selected healthy participants (mean age, 44.6 ± 20.1 years; 9 male) and patients with aortic stenosis (mean age, 78.3 ± 3.8 years; 7 male).SUBJECTSThis single-center study included a total of 28 participants (mean age, 56.6 ± 23.0 years; 16 male) consisting of randomly selected healthy participants (mean age, 44.6 ± 20.1 years; 9 male) and patients with aortic stenosis (mean age, 78.3 ± 3.8 years; 7 male).3 T, 3D multifrequency MRE with a single-shot spin-echo planar imaging sequence.FIELD STRENGTH/SEQUENCE3 T, 3D multifrequency MRE with a single-shot spin-echo planar imaging sequence.Each participant underwent two cardiac MMRE examinations on the same day. Full 3D wave fields were acquired in diastole at frequencies of 80, 90, and 100 Hz during a total of three breath-holds. Shear wave speed (SWS) and penetration rate (PR) were reconstructed as a surrogate for tissue stiffness and inverse viscous loss. Epicardial and endocardial ROIs were manually drawn by two independent readers to segment the LV myocardium.ASSESSMENTEach participant underwent two cardiac MMRE examinations on the same day. Full 3D wave fields were acquired in diastole at frequencies of 80, 90, and 100 Hz during a total of three breath-holds. Shear wave speed (SWS) and penetration rate (PR) were reconstructed as a surrogate for tissue stiffness and inverse viscous loss. Epicardial and endocardial ROIs were manually drawn by two independent readers to segment the LV myocardium.Shapiro-Wilk test, Bland-Altman analysis and intraclass correlation coefficient (ICC). P-value <0.05 were considered statistically significant.STATISTICAL TESTSShapiro-Wilk test, Bland-Altman analysis and intraclass correlation coefficient (ICC). P-value <0.05 were considered statistically significant.Bland-Altman analyses and intraclass correlation coefficients (ICC = 0.96 for myocardial stiffness and ICC = 0.93 for viscosity) indicated near-perfect test-retest repeatability among examinations on the same day. The mean SWS for scan and re-scan diastolic LV myocardium were 2.42 ± 0.24 m/s and 2.39 ± 0.23 m/s; the mean PR were 1.24 ± 0.17 m/s and 1.22 ± 0.14 m/s. Inter-reader variability showed good to excellent agreement for myocardial stiffness (ICC = 0.92) and viscosity (ICC = 0.85).RESULTSBland-Altman analyses and intraclass correlation coefficients (ICC = 0.96 for myocardial stiffness and ICC = 0.93 for viscosity) indicated near-perfect test-retest repeatability among examinations on the same day. The mean SWS for scan and re-scan diastolic LV myocardium were 2.42 ± 0.24 m/s and 2.39 ± 0.23 m/s; the mean PR were 1.24 ± 0.17 m/s and 1.22 ± 0.14 m/s. Inter-reader variability showed good to excellent agreement for myocardial stiffness (ICC = 0.92) and viscosity (ICC = 0.85).Cardiac MMRE is a promising and reproducible method for noninvasive assessment of diastolic LV stiffness and viscosity.DATA CONCLUSIONCardiac MMRE is a promising and reproducible method for noninvasive assessment of diastolic LV stiffness and viscosity.2 TECHNICAL EFFICACY: 1.LEVEL OF EVIDENCE2 TECHNICAL EFFICACY: 1. Background Cardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical challenges, mainly synchronization with cardiac cycle, breathing, and external harmonic stimulation. Purpose To determine the reproducibility of in vivo cardiac multifrequency MRE (MMRE) for assessing diastolic left ventricular (LV) stiffness and viscosity. Study Type Prospective. Subjects This single‐center study included a total of 28 participants (mean age, 56.6 ± 23.0 years; 16 male) consisting of randomly selected healthy participants (mean age, 44.6 ± 20.1 years; 9 male) and patients with aortic stenosis (mean age, 78.3 ± 3.8 years; 7 male). Field Strength/Sequence 3 T, 3D multifrequency MRE with a single‐shot spin‐echo planar imaging sequence. Assessment Each participant underwent two cardiac MMRE examinations on the same day. Full 3D wave fields were acquired in diastole at frequencies of 80, 90, and 100 Hz during a total of three breath‐holds. Shear wave speed (SWS) and penetration rate (PR) were reconstructed as a surrogate for tissue stiffness and inverse viscous loss. Epicardial and endocardial ROIs were manually drawn by two independent readers to segment the LV myocardium. Statistical Tests Shapiro–Wilk test, Bland–Altman analysis and intraclass correlation coefficient (ICC). P‐value <0.05 were considered statistically significant. Results Bland–Altman analyses and intraclass correlation coefficients (ICC = 0.96 for myocardial stiffness and ICC = 0.93 for viscosity) indicated near‐perfect test–retest repeatability among examinations on the same day. The mean SWS for scan and re‐scan diastolic LV myocardium were 2.42 ± 0.24 m/s and 2.39 ± 0.23 m/s; the mean PR were 1.24 ± 0.17 m/s and 1.22 ± 0.14 m/s. Inter‐reader variability showed good to excellent agreement for myocardial stiffness (ICC = 0.92) and viscosity (ICC = 0.85). Data Conclusion Cardiac MMRE is a promising and reproducible method for noninvasive assessment of diastolic LV stiffness and viscosity. Level of Evidence 2 Technical Efficacy 1 |
| Author | Lund, Morten A. V. Castelein, Johannes Dierckx, Rudi A. J. O. Kettless, Karen Hansen, Adam E. Duus, Amanda S. Anders, Matthias S. De Backer, Ole Borra, Ronald J. H. Vejlstrup, Niels G. Sack, Ingolf Bække, Pernille S. |
| AuthorAffiliation | 4 Department of Radiology Charite—Universitätsmedizin Berlin Berlin Germany 3 The Heart Centre Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark 6 Department of Radiology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark 5 Deparment of Research and Collaboration Siemens Healthcare A/S Ballerup Denmark 7 Department of Clinical Medicine University of Copenhagen Copenhagen Denmark 1 Department of Radiology University Medical Center Groningen Groningen The Netherlands 8 Department of Nuclear Medicine and Molecular Imaging University Medical Center Groningen Groningen The Netherlands 2 Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark |
| AuthorAffiliation_xml | – name: 8 Department of Nuclear Medicine and Molecular Imaging University Medical Center Groningen Groningen The Netherlands – name: 4 Department of Radiology Charite—Universitätsmedizin Berlin Berlin Germany – name: 2 Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark – name: 6 Department of Radiology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark – name: 3 The Heart Centre Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark – name: 5 Deparment of Research and Collaboration Siemens Healthcare A/S Ballerup Denmark – name: 1 Department of Radiology University Medical Center Groningen Groningen The Netherlands – name: 7 Department of Clinical Medicine University of Copenhagen Copenhagen Denmark |
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| Keywords | noninvasive left ventricle magnetic resonance elastography tissue stiffness tomoelastography |
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| Snippet | Background
Cardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical... Cardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical challenges, mainly... BackgroundCardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical challenges,... |
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| SubjectTerms | Adult Age Aged Aged, 80 and over Aorta Aortic stenosis Aortic Valve Stenosis - diagnostic imaging Correlation coefficient Correlation coefficients Diastole Elasticity Imaging Techniques - methods Female Field strength Heart Heart - diagnostic imaging Heart Ventricles - diagnostic imaging Humans Imaging, Three-Dimensional In vivo methods and tests left ventricle Magnetic properties Magnetic resonance magnetic resonance elastography Magnetic Resonance Imaging Male Males Middle Aged Myocardium noninvasive Prospective Studies Reproducibility Reproducibility of Results Statistical analysis Statistical tests Stiffness Synchronism Synchronization tissue stiffness tomoelastography Ventricle Ventricular Dysfunction, Left - diagnostic imaging Viscosity |
| Title | Reproducibility of Cardiac Multifrequency MR Elastography in Assessing Left Ventricular Stiffness and Viscosity |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjmri.29640 https://www.ncbi.nlm.nih.gov/pubmed/39449547 https://www.proquest.com/docview/3188759825 https://www.proquest.com/docview/3120597251 https://pubmed.ncbi.nlm.nih.gov/PMC11987795 |
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