Reproducibility of Cardiac Multifrequency MR Elastography in Assessing Left Ventricular Stiffness and Viscosity

• Published in: Journal of magnetic resonance imaging Vol. 61; no. 5; pp. 2146 - 2154
• Main Authors: Castelein, Johannes, Duus, Amanda S., Bække, Pernille S., Sack, Ingolf, Anders, Matthias S., Kettless, Karen, Hansen, Adam E., Dierckx, Rudi A. J. O., De Backer, Ole, Vejlstrup, Niels G., Lund, Morten A. V., Borra, Ronald J. H.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2025; Wiley Subscription Services, Inc
• Subjects: Adult; Age; Aged; Aged, 80 and over; Aorta; Aortic stenosis; Aortic Valve Stenosis - diagnostic imaging; Correlation coefficient; Correlation coefficients; Diastole; Elasticity Imaging Techniques - methods; Female; Field strength; Heart; Heart - diagnostic imaging; Heart Ventricles - diagnostic imaging; Humans; Imaging, Three-Dimensional; In vivo methods and tests; left ventricle; Magnetic properties; Magnetic resonance; magnetic resonance elastography; Magnetic Resonance Imaging; Male; Males; Middle Aged; Myocardium; noninvasive; Prospective Studies; Reproducibility; Reproducibility of Results; Statistical analysis; Statistical tests; Stiffness; Synchronism; Synchronization; tissue stiffness; tomoelastography; Ventricle; Ventricular Dysfunction, Left - diagnostic imaging; Viscosity; noninvasive; left ventricle; magnetic resonance elastography; tissue stiffness; tomoelastography
• ISSN: 1053-1807; 1522-2586; 1522-2586
• DOI: 10.1002/jmri.29640

Background Cardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical challenges, mainly synchronization with cardiac cycle, breathing, and external harmonic stimulation. Purpose To determine the reproducibility of in vivo cardiac multifrequency MRE (MMRE) for assessing diastolic left ventricular (LV) stiffness and viscosity. Study Type Prospective. Subjects This single‐center study included a total of 28 participants (mean age, 56.6 ± 23.0 years; 16 male) consisting of randomly selected healthy participants (mean age, 44.6 ± 20.1 years; 9 male) and patients with aortic stenosis (mean age, 78.3 ± 3.8 years; 7 male). Field Strength/Sequence 3 T, 3D multifrequency MRE with a single‐shot spin‐echo planar imaging sequence. Assessment Each participant underwent two cardiac MMRE examinations on the same day. Full 3D wave fields were acquired in diastole at frequencies of 80, 90, and 100 Hz during a total of three breath‐holds. Shear wave speed (SWS) and penetration rate (PR) were reconstructed as a surrogate for tissue stiffness and inverse viscous loss. Epicardial and endocardial ROIs were manually drawn by two independent readers to segment the LV myocardium. Statistical Tests Shapiro–Wilk test, Bland–Altman analysis and intraclass correlation coefficient (ICC). P‐value <0.05 were considered statistically significant. Results Bland–Altman analyses and intraclass correlation coefficients (ICC = 0.96 for myocardial stiffness and ICC = 0.93 for viscosity) indicated near‐perfect test–retest repeatability among examinations on the same day. The mean SWS for scan and re‐scan diastolic LV myocardium were 2.42 ± 0.24 m/s and 2.39 ± 0.23 m/s; the mean PR were 1.24 ± 0.17 m/s and 1.22 ± 0.14 m/s. Inter‐reader variability showed good to excellent agreement for myocardial stiffness (ICC = 0.92) and viscosity (ICC = 0.85). Data Conclusion Cardiac MMRE is a promising and reproducible method for noninvasive assessment of diastolic LV stiffness and viscosity. Level of Evidence 2 Technical Efficacy 1