Cellular and humoral local immune responses in sheep experimentally infected with Oestrus ovis (Diptera: Oestridae)

• Published in: Veterinary research (Paris) Vol. 34; no. 2; pp. 231 - 241
• Main Authors: Tabouret, G. ((Ecole Nationale Vétérinaire de Toulouse (France). UMR de Physiopathologie Infectieuse et Parasitaire des Ruminants)), Lacroux, C, Andreoletti, O, Bergeaud, J.P, Hailu-Tolosa, Y, Hoste, H, Prevot, F, Grisez, C, Dorchies, P, Jacquiet, P
• Format: Journal Article
• Language: English
• Published: Les Ulis EDP Sciences 01.03.2003; BioMed Central
• Subjects: Animal biology; Animal genetics; Animal productions; Animals; Antibodies - immunology; Biochemistry, Molecular Biology; Biological and medical sciences; Cell Behavior; Cellular Biology; Diptera - immunology; Diptera - physiology; EXPERIMENTAL INFECTION; Female; Fundamental and applied biological sciences. Psychology; Genetics; Granulocytes - immunology; IMMUNE RESPONSE; Immunoglobulin A - immunology; Immunoglobulin G - immunology; IMMUNOGLOBULINE; IMMUNOGLOBULINS; Immunology; INFECCION EXPERIMENTAL; INFECTION EXPERIMENTALE; INMUNOGLOBULINA; Larva - immunology; Larva - physiology; Leukocytes - immunology; Life Sciences; LINFOCITOS; LYMPHOCYTE; LYMPHOCYTES; Male; Microbiology and Parasitology; Molecular biology; Myiasis - immunology; Myiasis - parasitology; Myiasis - veterinary; Nasal Mucosa - immunology; Nasopharynx - immunology; Neurons and Cognition; OESTRUS OVIS; OVIN; OVINOS; REPONSE IMMUNITAIRE; RESPUESTA INMUNOLOGICA; Salivary Glands - immunology; Santé publique et épidémiologie; SHEEP; Sheep, Domestic - immunology; Sheep, Domestic - parasitology; Terrestrial animal productions; Vertebrates; Immune response; Insecta; Oestrus ovis I local immune response; Cellular immunity; Parasitosis; IgA and IgG immunoglobulins; lymphocyte; Infection; Oestridae; Vertebrata; Experimental disease; Mammalia; Arthropoda; Oestrus ovis; Sheep; Artiodactyla; Invertebrata; Veterinary; eosinophil; Diptera; Ungulata; Humoral immunity; local immune response
• ISSN: 0928-4249; 1297-9716
• DOI: 10.1051/vetres:2002070

Cellular and humoral local responses were investigated following repetitive artificial Oestrus ovis infections in lambs. The presence of larvae induced a huge local recruitment of either leukocytes (T and B lymphocytes, macrophages) or granulocytes (eosinophils, mast cells and globule leucocytes). This cellular response was more pronounced in the ethmoid and sinus (development sites of second and third instar larvae) than in the septum or turbinates where first instar larvae migrate. Infected lambs produced Oestrus ovis specific IgG and IgA antibodies in their mucus. This local humoral response was mainly directed against larval salivary gland antigens and not against larval digestive tract antigens. Compared to the control animals, the sinusal mucosa of infected animals was extremely thickened and the epithelium exhibited hyperplasia, metaplasia and eosinophilic exocytosis. The possible roles of these local immune responses in the regulation of O. ovis larvae populations in sheep are discussed