The dynamic relationship of gut microbiota with sex hormones in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease. The sex hormones estrogen and testosterone may have an influence on the production of antibodies. In addition, the gut microbiota also shows an effect on the onset and progression of SLE. Hence, the molecular interplay betwee...

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Bibliographic Details
Published inReumatologia Vol. 61; no. 2; pp. 130 - 136
Main Authors Katrib, Marcel, Haddad, Rafi, Hamdan, Zahi, Rida, Mohamad Ali
Format Journal Article
LanguageEnglish
Published Poland Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 01.01.2023
Termedia Publishing House
Subjects
autoimmunity
gut microbiota
molecular mimicry
Review Paper
sex hormones
systemic lupus erythematosus
molecular mimicry
systemic lupus erythematosus
autoimmunity
sex hormones
gut microbiota
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Summary:Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease. The sex hormones estrogen and testosterone may have an influence on the production of antibodies. In addition, the gut microbiota also shows an effect on the onset and progression of SLE. Hence, the molecular interplay between sex hormones in terms of gender difference, gut microbiota and SLE is being clarified day after day. The aim of this review is to investigate the dynamic relationship of the gut microbiota with sex hormones in systemic lupus erythematosus taking into account the bacterial strains shown to be affected, effects of antibiotics and other factors that affect the gut microbiome, which itself strongly affects the pathogenesis of SLE.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0034-6233
2084-9834
DOI:10.5114/reum/163091