Host-parasite relations in mouse typhoid

The development of acquired resistance to Salmonella typhimurium has been studied in mice infected intravenously with small numbers of streptomycin-sensitive or streptomycin-resistant organisms. By the 14th day of a primary infection the mouse develops a mechanism capable of destroying completely a...

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Bibliographic Details
Published inThe Journal of experimental medicine Vol. 124; no. 4; pp. 573 - 583
Main Authors Mackaness, G B, Blanden, R V, Collins, F M
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 01.10.1966
Subjects
Animals
Mice
Typhoid Fever - immunology
Typhoid-Paratyphoid Vaccines
Vaccination
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Summary:The development of acquired resistance to Salmonella typhimurium has been studied in mice infected intravenously with small numbers of streptomycin-sensitive or streptomycin-resistant organisms. By the 14th day of a primary infection the mouse develops a mechanism capable of destroying completely a super infecting dose of organisms, but is unable to eliminate organisms of the primary infection. The latter are constantly returned to the circulation from necrotic foci at the sites of implantation. Passive transfer of serum from actively infected or vaccinated animals, and immunization with heat-killed organisms, increase the capacity of the host to clear organisms from the blood, but do not interfere to any significant extent with their subsequent multiplication in the tissues. It is concluded that the resistance of actively infected animals depends on a nonhumoral mechanism capable of destroying organisms from endogenous or exogenous sources.
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ISSN:0022-1007
1540-9538
DOI:10.1084/jem.124.4.573