Relationship between soluble receptor for advanced glycation end products (sRAGE), body composition and fat distribution in healthy women

• Published in: European journal of nutrition Vol. 56; no. 8; pp. 2557 - 2564
• Main Authors: Dozio, Elena, Briganti, Silvia, Delnevo, Alessandra, Vianello, Elena, Ermetici, Federica, Secchi, Francesco, Sardanelli, Francesco, Morricone, Lelio, Malavazos, Alexis E., Corsi Romanelli, Massimiliano M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2017; Springer Nature B.V
• Subjects: Adipose tissue; Adiposity; Adult; adults; advanced glycation end products; Advanced glycosylation end products; bioelectrical impedance; biomarkers; Biomarkers - blood; Blood Glucose - metabolism; Body Composition; Body fat; Body Fat Distribution; Body Mass Index; Chemistry; Chemistry and Materials Science; Cholesterol - blood; Enzyme-linked immunosorbent assay; Fat-free body mass; Female; Glycosylation; Humans; lean body mass; ligands; Magnetic resonance imaging; Nutrition; Obesity; Obesity - blood; Original Contribution; Receptor for Advanced Glycation End Products - blood; regression analysis; risk; tissue distribution; Triglycerides - blood; visceral fat; Waist Circumference; women; Women's Health; Womens health; Visceral adipose tissue; Adipose tissue; Receptor for advanced glycation end products; Subcutaneous adipose tissue; Adipose tissue distribution; Epicardial adipose tissue
• ISSN: 1436-6207; 1436-6215
• DOI: 10.1007/s00394-016-1291-0

Purpose Soluble receptor for advanced glycation end products (sRAGE) is a decoy receptor which sequesters RAGE ligands and acts as a cytoprotective agent. To date, it is unclear whether the lower sRAGE levels observed in obesity are a marker of increased overall adiposity or reflect increases in particular fat depots. Therefore, we evaluated in healthy women the relationship among sRAGE and indicators of adiposity, including abdominal visceral (VAT) and epicardial visceral (EAT) adipose tissues, to explore the potential role of sRAGE as an earlier biomarker of cardiometabolic risk. Methods Plasma sRAGE levels were quantified by an enzyme-linked immunosorbent assay in 47 healthy women. Total fat mass (FM) and fat-free mass were estimated with bioimpedance analysis. Anthropometric measures and biochemical data were recorded. Subcutaneous adipose tissue, VAT and EAT volumes were measured by magnetic resonance imaging. Results Obese women had lower sRAGE levels compared to normal-weight women. sRAGE levels were also lower in women with a waist circumference (WC) larger than 80 cm. Correlation analyses indicated an inverse association of sRAGE with body mass index and FM. Concerning adipose tissue distribution, sRAGE inversely correlated with WC, EAT and VAT depots. In a multiple stepwise regression analysis, performed to emphasize the role of fat distribution, EAT volume was the only predictor of sRAGE. Conclusions Lower sRAGE levels reflect accumulation of visceral fat mainly at the epicardial level and are present in advance of metabolic complications in adult women. sRAGE quantification might be an early marker of cardiometabolic risk.