Tensor-Based Morphometry Reveals Volumetric Deficits in Moderate/Severe Pediatric Traumatic Brain Injury

• Published in: Journal of neurotrauma Vol. 33; no. 9; pp. 840 - 852
• Main Authors: Dennis, Emily L., Hua, Xue, Villalon-Reina, Julio, Moran, Lisa M., Kernan, Claudia, Babikian, Talin, Mink, Richard, Babbitt, Christopher, Johnson, Jeffrey, Giza, Christopher C., Thompson, Paul M., Asarnow, Robert F.
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.05.2016
• Subjects: Adolescent; Adults; Atrophy; Brain - diagnostic imaging; Brain - pathology; Brain Injuries, Traumatic - diagnostic imaging; Brain Injuries, Traumatic - pathology; Brain Injuries, Traumatic - psychology; Brain research; Child; Children & youth; Cohort Studies; Cross-Sectional Studies; Deformation; Female; Humans; Intensive care; Intensive Care Units, Pediatric; Magnetic Resonance Imaging - methods; Male; Medicine; Neurosciences; Original; Pediatrics; Psychiatry; Regions; Traumatic brain injury; Young Adult; Los Angeles California; Marina del Rey California; California; United States > US; traumatic brain injury; tensor based morphometry; MRI; pediatric
• ISSN: 0897-7151; 1557-9042; 1557-9042
• DOI: 10.1089/neu.2015.4012

Traumatic brain injury (TBI) can cause widespread and prolonged brain degeneration. TBI can affect cognitive function and brain integrity for many years after injury, often with lasting effects in children, whose brains are still immature. Although TBI varies in how it affects different individuals, image analysis methods such as tensor-based morphometry (TBM) can reveal common areas of brain atrophy on magnetic resonance imaging (MRI), secondary effects of the initial injury, which will differ between subjects. Here we studied 36 pediatric moderate to severe TBI (msTBI) participants in the post-acute phase (1-6 months post-injury) and 18 msTBI participants who returned for their chronic assessment, along with well-matched controls at both time-points. Participants completed a battery of cognitive tests that we used to create a global cognitive performance score. Using TBM, we created three-dimensional (3D) maps of individual and group differences in regional brain volumes. At both the post-acute and chronic time-points, the greatest group differences were expansion of the lateral ventricles and reduction of the lingual gyrus in the TBI group. We found a number of smaller clusters of volume reduction in the cingulate gyrus, thalamus, and fusiform gyrus, and throughout the frontal, temporal, and parietal cortices. Additionally, we found extensive associations between our cognitive performance measure and regional brain volume. Our results indicate a pattern of atrophy still detectable 1-year post-injury, which may partially underlie the cognitive deficits frequently found in TBI.