Increased Propensity for Central Apnea in Patients with Obstructive Sleep Apnea: Effect of Nasal Continuous Positive Airway Pressure

• Published in: American journal of respiratory and critical care medicine Vol. 181; no. 2; pp. 189 - 193
• Main Authors: Salloum, Anan, Rowley, James A, Mateika, Jason H, Chowdhuri, Susmita, Omran, Qasim, Badr, M. Safwan
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 15.01.2010; American Thoracic Society
• Subjects: Adult; Airway management; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Carbon Dioxide - blood; Chemoreceptor Cells - physiology; Continuous Positive Airway Pressure; Controllers; Emergency and intensive respiratory care; Female; G. Sleep and Control of Ventilation; Humans; Hyperventilation; Hypocapnia - diagnosis; Hypocapnia - physiopathology; Hypocapnia - therapy; Intensive care medicine; Male; Medical sciences; Middle Aged; Polysomnography; Reflex - physiology; Respiratory Mechanics - physiology; Sensory Thresholds - physiology; Sleep apnea; Sleep Apnea, Central - blood; Sleep Apnea, Central - physiopathology; Sleep Apnea, Obstructive - diagnosis; Sleep Apnea, Obstructive - physiopathology; Sleep Apnea, Obstructive - therapy; Sleep Stages - physiology; Ventilators; Human; obstructive sleep apnea; Nervous system diseases; Intensive care; Sleep apnea syndrome; Respiratory disease; complex sleep apnea; controller gain; Apnea; Positive pressure; apneic threshold; central sleep apnea; Resuscitation; control of breathing

There is increasing evidence of increased ventilatory instability in patients with obstructive sleep apnea (OSA), but previous investigations have not studied whether the hypocapnic apneic threshold is altered in this group. To compare the apneic threshold, CO2 reserve, and controller gain between s...