Effects of EDTA on signal stability during electrochemical detection of acetaminophen

The use of EDTA in the medium to avoid the passivation of a solid electrode during electrochemical analysis of acetaminophen is presented in this work. The performance of this system was investigated with respect to pH, applied potential and supporting electrolyte concentration. The major advantage...

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Bibliographic Details
Published inJournal of pharmaceutical and biomedical analysis Vol. 34; no. 5; pp. 871 - 878
Main Authors de Carvalho, Rosangela M, Freire, Renato S, Rath, Susanne, Kubota, Lauro T
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 10.03.2004
Elsevier Science
Subjects
Acetaminophen
Acetaminophen - analysis
Analysis
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Edetic Acid - analysis
EDTA
Electroanalytical
Electrochemistry
Flow Injection Analysis - instrumentation
Flow Injection Analysis - methods
Fundamental and applied biological sciences. Psychology
General pharmacology
High performance method
Medical sciences
Pharmacology. Drug treatments
Solid electrodes
EDTA
High performance method
Acetaminophen
Electroanalytical
Solid electrodes
Antimigrainous agent
Electrochemical detector
Paracetamol
Sensitivity
Analgesic
Electrolyte
Antipyretic
Chelating agent
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Summary:The use of EDTA in the medium to avoid the passivation of a solid electrode during electrochemical analysis of acetaminophen is presented in this work. The performance of this system was investigated with respect to pH, applied potential and supporting electrolyte concentration. The major advantage in using EDTA in the supporting electrolyte is the significant increase in sensitivity, precision and stability of the measurements, when compared to the system in absence of the chelating agent. The sensitivity increases 5.5 times (21.5 and 3.9mAlmol−1 in the presence and the absence of EDTA, respectively), the repeatability (n=20) is 3.5 times better, expressed by within-run-precision of 4.0% for 6.0×10−5moll−1 acetaminophen in the presence of EDTA while, in its absence, the within-run-precision was higher than 14%. Moreover, the system showed excellent stability, allowing more than 120 measurements with no significant changes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2003.11.005