The synergistic effect of vascular cell adhesion molecule-1 and coronary artery disease on brain-derived neurotrophic factor

• Published in: Clinica Chimica Acta Vol. 466; pp. 194 - 200
• Main Authors: Lee, I-Te, Wang, Jun-Sing, Lee, Wen-Jane, Lin, Shih-Yi, Fu, Chia-Po, Liang, Kae-Woei, Hsu, Chiann-Yi, Sheu, Wayne Huey-Herng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2017; Elsevier BV
• Subjects: Angina Pectoris; Area Under Curve; Brain-Derived Neurotrophic Factor; Brain-Derived Neurotrophic Factor - blood; Case-Control Studies; Coronary Artery Disease; Coronary Artery Disease - blood; Glucose Tolerance Test; Humans; Oral glucose tolerance test; Predictive Value of Tests; Time Factors; Vascular Cell Adhesion Molecule-1; Vascular Cell Adhesion Molecule-1 - blood; Oral glucose tolerance test; TNFα; ACE; BDNF; RAS; IL-1β; Coronary artery disease; BP; LPS; ARB; Brain-derived neurotrophic factor; PC; ANOVA; LDL; Vascular cell adhesion molecule-1; TLR; OGTT
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2017.01.026

Brain-derived neurotrophic factor (BDNF) is important for neural protection and energy homeostasis. In this study, we examined the effects of vascular cell adhesion molecule-1 (VCAM-1) and coronary artery disease (CAD) on BDNF. Subjects who had undergone diagnostic angiography for angina were recruited, and a total of 240 subjects (144 with CAD and 96 without CAD) were enrolled. Serum BDNF was determined at 0, 30, and 120min during an oral glucose tolerance test (OGTT) to calculate the area under the curve (AUC) for BDNF. Serum VCAM-1 was determined at fasting. Significantly lower AUC of BDNF (42.8±10.7 vs. 47.4±11.7ng-h/ml, P=0.002) and higher serum VCAM-1 (583±383 vs. 482±171ng/ml, P=0.017) were noted in subjects with CAD compared to those without CAD. High VCAM-1 level was an independent predictor of low AUC of BDNF in subjects with and without CAD (95%CI between −0.011 and −0.002, P=0.008; −0.033 and −0.002, P=0.029, respectively). Serum BDNF was lowest in the CAD subjects with high VCAM-1 levels at all time points during OGTT. Our results showed that CAD was associated with low serum BDNF in response to OGTT, and VCAM-1 had a synergistic effect with CAD on the BDNF. •Brain-derived neurotrophic factor (BDNF) deficiency is associated with depression.•BDNF is important in energy homeostasis and its level changes in response to intake.•Area under the curve (AUC) of serum BDNF is seldom assessed after glucose intake.•AUC of serum BDNF decreased in the subjects with CAD.•There is a synergistic effect of VCAM-1 and CAD on reduction in AUC of serum BDNF.