Follicular-Stimulating Hormone, Luteinizing Hormone, and Prolactin Serum Level in Patients with Oral Lichen Planus in Comparison to Healthy Population

• Published in: BioMed research international Vol. 2021; pp. 8679505 - 7
• Main Authors: Lavaee, Fatemeh, Bazrafkan, Nazila, Zarei, Fateme, Sardo, Maryam Shahrokhi
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; Hindawi Limited
• Subjects: Adult; Age; Autoimmune diseases; Biomedical research; Case-Control Studies; Cross-Sectional Studies; Cytotoxicity; Data analysis; Dental materials; Disease; Estradiol - blood; Estrogens; Female; Follicle Stimulating Hormone - blood; Follicle Stimulating Hormone, Human - blood; Follicle Stimulating Hormone, Human - metabolism; Follicle-stimulating hormone; Gonadotropin-Releasing Hormone - blood; Hormones; Humans; Lichen planus; Lichen Planus, Oral - blood; Lichen Planus, Oral - metabolism; Luteinizing hormone; Luteinizing Hormone - blood; Luteinizing Hormone - metabolism; Maxillofacial; Menopause; Middle Aged; Pathogenesis; Progesterone; Progesterone - blood; Prolactin; Prolactin - analysis; Prolactin - blood; Sample size; Sex hormones; Variance analysis; Womens health
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2021/8679505

Aim and Background. Autoimmune diseases are more common in women; also, some relations have been reported between some sexual hormones and autoimmune diseases. In this study, we aimed to evaluate any possible relation of FSH, LH, and prolactin level and oral lichen planus (OLP). Materials and Methods. In this cross-sectional case control study, the serum level of LH, FSH, and prolactin of 40 women with lichen planus who have been referred to Shiraz Dental Faculty, Oral and Maxillofacial Disease Department during 2018-2019 has been evaluated in comparison to 40 healthy controls. Data were analyzed by SPSS version 18. Two-way ANOVA and Mann–Whitney test were used for data analysis. Results. The mean serum level of FSH and LH was significantly higher in OLP patients while this difference was not reported for prolactin. Only FSH mean serum level was significantly higher in nonmenopausal OLP patients. The distribution of prolactin and FSH hormones’ serum level was in normal range. Conclusions. The high serum level of FSH and LH can affect OLP pathogenesis by estrogen and progesterone modulation.