Host factors regulating post-integration latency of HIV

A recent study has provided important clues towards the identity of the host genes that conspire to promote post-integration latency of human immunodeficiency virus (HIV). Various genes controlling transcription, histone deacetylation and proteasome-mediated protein degradation have emerged as poten...

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Bibliographic Details
Published inTrends in microbiology (Regular ed.) Vol. 13; no. 4; pp. 137 - 139
Main Authors Williams, Samuel A.F., Greene, Warner C.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2005
Subjects
CD4-Positive T-Lymphocytes - physiology
CD4-Positive T-Lymphocytes - virology
Gene Expression Regulation, Viral
HIV - genetics
HIV - physiology
Human immunodeficiency virus
Humans
Proviruses - genetics
Proviruses - physiology
Virus Integration - genetics
Virus Latency - genetics
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Summary:A recent study has provided important clues towards the identity of the host genes that conspire to promote post-integration latency of human immunodeficiency virus (HIV). Various genes controlling transcription, histone deacetylation and proteasome-mediated protein degradation have emerged as potential players. If the desired, but difficult, goal of complete virus eradication in HIV-infected patients is ever to be realized, the latent reservoir of HIV proviruses must be cleared. Understanding the molecular basis for viral latency is the key first step.
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ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2005.02.006