Nanostructured microfluidic digestion system for rapid high-performance proteolysis

A novel microfluidic protein digestion system with a nanostructured and bioactive inner surface was constructed by an easy biomimetic self-assembly strategy for rapid and effective proteolysis in 2 minutes, which is faster than the conventional overnight digestion methods. It is expected that this w...

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Bibliographic Details
Published inLab on a chip Vol. 15; no. 3; pp. 650 - 654
Main Authors Cheng, Gong, Hao, Si-Jie, Yu, Xu, Zheng, Si-Yang
Format Journal Article
LanguageEnglish
Published England 07.02.2015
Subjects
Biocompatibility
Digestion
Lab-On-A-Chip Devices
Microfluidics
Models, Molecular
Nanostructure
Nanostructures - chemistry
Particle Size
Proteins
Proteolysis
Proteomics
Self assembly
Strategy
Surface Properties
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Summary:A novel microfluidic protein digestion system with a nanostructured and bioactive inner surface was constructed by an easy biomimetic self-assembly strategy for rapid and effective proteolysis in 2 minutes, which is faster than the conventional overnight digestion methods. It is expected that this work would contribute to rapid online digestion in future high-throughput proteomics.
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ISSN:1473-0197
1473-0189
DOI:10.1039/c4lc01165a