Influence of the Young’s Modulus of Polyurethane Implants on the Organism’s Immune Response

A series of polyurethanes with low modulus of elasticity for soft tissue implantation was synthesized. Polyurethane samples were implanted into mice for seven days, after which histological studies of capsule formation were carried out. The mechanical properties of polyurethane were found to affect...

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Bibliographic Details
Published inBiomedical engineering Vol. 52; no. 6; pp. 431 - 434
Main Authors Kondyurina, I. V., Chudinov, V. S., Terpugov, V. N., Kondyurin, A. V.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2019
Springer
Springer Nature B.V
Subjects
Biomaterials
Biomechanics
Biomedical Engineering and Bioengineering
Deformation
Engineering
Ethanol
Humidity
Immune response
Immune system
Implantation
Implants
Laboratory animals
Mechanical properties
Modulus of elasticity
Plastic products
Polyethylene glycol
Polyurethane
Polyurethane resins
Polyurethanes
Soft tissues
Spectrum analysis
Surgery
Sutures
Transplants & implants
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Summary:A series of polyurethanes with low modulus of elasticity for soft tissue implantation was synthesized. Polyurethane samples were implanted into mice for seven days, after which histological studies of capsule formation were carried out. The mechanical properties of polyurethane were found to affect the organism’s immune response at sites close to implants at which specific conditions concentrating biomechanical stress in tissues, particularly around the ends of polyurethane films, occur. Softer polyurethane with a modulus of elasticity close to the modulus of elasticity of tissues produced essentially no reaction to biomechanical stress, though reactions to the foreign surface of the implant remained.
ISSN:0006-3398
1573-8256
DOI:10.1007/s10527-019-09863-7