Simultaneous determination of lidocaine, mexiletine, disopyramide, and quinidine in plasma by high performance liquid chromatography

A high performance liquid chromatographic method is described for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: lidocaine, mexiletine, disopyramide, and quinidine. An isocratic system using a reverse phase column was used to separate these compounds. Coefficients of...

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Bibliographic Details
Published inJournal of analytical toxicology Vol. 9; no. 2; p. 67
Main Authors Dusci, L J, Hackett, L P
Format Journal Article
LanguageEnglish
Published England 01.03.1985
Subjects
Anti-Arrhythmia Agents - blood
Chromatography, High Pressure Liquid
Disopyramide - blood
Humans
Lidocaine - analogs & derivatives
Lidocaine - blood
Mexiletine - blood
Quinidine - blood
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Summary:A high performance liquid chromatographic method is described for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: lidocaine, mexiletine, disopyramide, and quinidine. An isocratic system using a reverse phase column was used to separate these compounds. Coefficients of variation were less than 4%.
ISSN:0146-4760
DOI:10.1093/jat/9.2.67