Targeting shared pathways in tauopathies and age-related macular degeneration: implications for novel therapies

The intricate parallels in structure and function between the human retina and the central nervous system designate the retina as a prospective avenue for understanding brain-related processes. This review extensively explores the shared physiopathological mechanisms connecting age-related macular d...

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Published inFrontiers in aging neuroscience Vol. 16; p. 1371745
Main Authors Rinaldi, Michele, Pezone, Antonio, Quadrini, Gaia Italia, Abbadessa, Gianmarco, Laezza, Maria Paola, Passaro, Maria Laura, Porcellini, Antonio, Costagliola, Ciro
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 03.04.2024
Frontiers Media S.A
Subjects
Age
age-related macular degeneration
Alzheimer’s disease
amyloid-β
Biomarkers
Brain
Central nervous system
Chronic traumatic encephalopathy
Dementia
Disease
drusen
Macular degeneration
Nervous system
Neurodegeneration
Neurodegenerative diseases
Neuropathology
Neuroscience
Oxidative stress
Pathology
Peptides
Proteins
Retina
Senescence
Signal transduction
Structure-function relationships
Tau protein
tauopathies
amyloid-β
tauopathies
Alzheimer’s disease
age-related macular degeneration
oxidative stress
drusen
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Summary:The intricate parallels in structure and function between the human retina and the central nervous system designate the retina as a prospective avenue for understanding brain-related processes. This review extensively explores the shared physiopathological mechanisms connecting age-related macular degeneration (AMD) and proteinopathies, with a specific focus on tauopathies. The pivotal involvement of oxidative stress and cellular senescence emerges as key drivers of pathogenesis in both conditions. Uncovering these shared elements not only has the potential to enhance our understanding of intricate neurodegenerative diseases but also sets the stage for pioneering therapeutic approaches in AMD.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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Edited by: Mattéa J. Finelli, University of Nottingham, United Kingdom
Reviewed by: Goran Petrovski, University of Oslo, Norway
Serena Fragiotta, Sapienza University of Rome, Italy
These authors have contributed equally to this work and share first authorship
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2024.1371745