Immunomodulatory effects of lactoferrin

Lactoferrin （Lf） is an iron-binding glycoprotein of the transferrin family, which is expressed in most biological fluids with particularly high levels in mammalian milk. Its multiple activities lie in its capacity to bind iron and to interact with the molecular and cellular components of hosts and p...

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Published inActa pharmacologica Sinica Vol. 35; no. 5; pp. 557 - 566
Main Author Tania SIQUEIROS-CENDON Sigifredo AREVALO-GALLEGOS Blanca Flor IGLESIAS-FIGUEROA Isui Abril GARCiA-MONTOYA Jose SALAZAR-MARTIN EZ Quintin RASCON-CRUZ
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.05.2014
Nature Publishing Group
Subjects
Adaptive Immunity - drug effects
Adaptive Immunity - immunology
Animals
Biomedical and Life Sciences
Biomedicine
Humans
Immunity, Innate - drug effects
Immunity, Innate - immunology
Immunologic Factors - immunology
Immunologic Factors - pharmacology
Immunologic Factors - therapeutic use
Immunology
Internal Medicine
Lactoferrin - immunology
Lactoferrin - pharmacology
Lactoferrin - therapeutic use
Medical Microbiology
Pharmacology/Toxicology
Review
Vaccine
乳铁蛋白
免疫调节作用
哺乳动物
相互作用
组织损伤
细胞成分
转铁蛋白
铁结合糖蛋白
lactoferrin
transferring
antimicrobial
immunomodulator
glycoprotein
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ISSN1671-4083
1745-7254
1745-7254
DOI10.1038/aps.2013.200

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Summary:Lactoferrin （Lf） is an iron-binding glycoprotein of the transferrin family, which is expressed in most biological fluids with particularly high levels in mammalian milk. Its multiple activities lie in its capacity to bind iron and to interact with the molecular and cellular components of hosts and pathogens. Lf can bind and sequester lipopolysaccharides, thus preventing pro-inflammatory pathway activation, sepsis and tissue damages. Lf is also considered a cell-secreted mediator that bridges the innate and adaptive immune responses. In the recent years much has been learned about the mechanisms by which Lf exerts its activities. This review summarizes the recent advances in understanding the mechanisms underlying the multifunctional roles of Lf, and provides a future perspective on its potential prophylactic and therapeutic applications.
Bibliography:lactoferrin; glycoprotein; transferring; immunomodulator; antimicrobial
Lactoferrin （Lf） is an iron-binding glycoprotein of the transferrin family, which is expressed in most biological fluids with particularly high levels in mammalian milk. Its multiple activities lie in its capacity to bind iron and to interact with the molecular and cellular components of hosts and pathogens. Lf can bind and sequester lipopolysaccharides, thus preventing pro-inflammatory pathway activation, sepsis and tissue damages. Lf is also considered a cell-secreted mediator that bridges the innate and adaptive immune responses. In the recent years much has been learned about the mechanisms by which Lf exerts its activities. This review summarizes the recent advances in understanding the mechanisms underlying the multifunctional roles of Lf, and provides a future perspective on its potential prophylactic and therapeutic applications.
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ISSN:1671-4083
1745-7254
1745-7254
DOI:10.1038/aps.2013.200